Denenberg V H, Hoplight B, Sherman G F, Mobraaten L E
Biobehavioral Sciences Graduate Degree Program, University of Connecticut, Storrs, CT 06269-4154, USA.
Dev Psychobiol. 2001 Apr;38(3):154-63. doi: 10.1002/dev.1009.
Between 40-60% of BXSB-Yaa+mice have neocortical ectopias, a genetically based brain anomaly. The presence of ectopias is known to affect several cognitive measures. A second way to affect cognition is by transferring embryos into foreign uteri. These variables were jointly investigated in three experiments. BXSB-Yaa+mouse embryos were transferred into same-strain uteri, or into uteri of hybrid mice. At birth, pups were cross-fostered to hybrid mothers or were reared by their birth mothers. When adult, the mice were given a series of behavioral tests with primary emphasis upon cognitive competence. Across all three studies, mice transferred into hybrid uteri were superior in the Morris maze and the Lashley III maze, and performed more effectively in shuttlebox avoidance learning. They were less effective in the simple water escape task, and the uterus groups did not differ in discrimination learning. Thus, development within a foreign uterus enhanced spatial learning and fear-based conditioning. Ectopic mice were superior to non-ectopics in learning the Morris maze, a finding consistent with prior research using the congenic BXSB-Yaa strain. There were Uterus x Ectopia interactions on a few measures, indicating that, under certain condition, whether the presence of ectopias is beneficial or detrimental is contingent upon the uterine environment within which the organism develops.
40%至60%的BXSB - Yaa +小鼠存在新皮质异位，这是一种基于基因的脑部异常。已知异位的存在会影响多种认知指标。影响认知的另一种方式是将胚胎移植到异体子宫中。在三个实验中对这些变量进行了联合研究。将BXSB - Yaa +小鼠胚胎移植到同品系子宫或杂种小鼠子宫中。出生时，幼崽被交叉寄养给杂种母亲或由其生母抚养。成年后，对小鼠进行了一系列行为测试，主要侧重于认知能力。在所有三项研究中，移植到杂种子宫中的小鼠在莫里斯迷宫和拉什利三世迷宫中表现更优，并且在穿梭箱回避学习中表现更有效。它们在简单的水逃避任务中效果较差，并且子宫组在辨别学习方面没有差异。因此，在异体子宫内发育增强了空间学习和基于恐惧的条件反射。异位小鼠在学习莫里斯迷宫方面优于非异位小鼠，这一发现与之前使用同源BXSB - Yaa品系的研究一致。在一些指标上存在子宫×异位的相互作用，表明在某些情况下，异位的存在是有益还是有害取决于生物体发育所处的子宫环境。
