Gündüz I, López-Fuster M J, Ventura J, Searle J B
Department of Biology, University of York, PO Box 373, York YO10 5YW, UK.
Genet Res. 2001 Feb;77(1):41-51. doi: 10.1017/s0016672300004808.
These studies centre on the 'Barcelona' karyotypic race of the western house mouse (Mus musculus domesticus), first described by Adolph & Klein (1981). This is one of many races within M. m. domesticus characterized by metacentric chromosomes that have originated by repeated Robertsonian fusions, with perhaps further modification by whole-arm reciprocal translocations. Data on 111 mice from 20 sites show that the race is centred 24 km to the west of Barcelona city and has a homozygous metacentric karyotype of 2n = 28 (3.8, 4.14, 5.15, 6.10, 9.11, 12.13). The race has a small range, and mice with the standard 40-acrocentric karyotype were caught only 30 km from the race centre. Throughout the area of occurrence of metacentrics there is polymorphism (i.e. presence of acrocentrics in the population), although all six metacentrics approach fixation close to the race centre. Thus, there is a hybrid zone between the Barcelona and standard races. The centres and widths of all clines (except 3.8) were determined. Likelihood ratio tests showed that most of the cline centres differed significantly in position (i.e. the clines were staggered) and the clines for metacentrics 6.10 and 9.11 were significantly narrower than those for 4.14, 5.15 and 12.13. Overall, the clines tended to be wider the further they were from the race centre. There are various possible explanations for this hybrid zone structure and further data are needed to distinguish between them.
这些研究聚焦于西方家鼠（小家鼠）的“巴塞罗那”核型族，该族由阿道夫和克莱因于1981年首次描述。这是小家鼠众多族中的一员，其特征是中着丝粒染色体由反复的罗伯逊融合产生，可能还经过了全臂相互易位的进一步修饰。来自20个地点的111只小鼠的数据表明，该族集中在巴塞罗那市以西24公里处，具有纯合的中着丝粒核型，2n = 28（3.8、4.14、5.15、6.10、9.11、12.13）。该族分布范围较小，具有标准40条近端着丝粒核型的小鼠仅在距该族中心30公里处被捕获。在整个中着丝粒出现的区域存在多态性（即种群中存在近端着丝粒），尽管所有六条中着丝粒在接近该族中心处都接近固定状态。因此，在巴塞罗那族和标准族之间存在一个杂交带。确定了所有渐变群（除3.8外）的中心和宽度。似然比检验表明，大多数渐变群中心在位置上有显著差异（即渐变群交错），中着丝粒6.10和9.11的渐变群明显比4.14、5.15和12.13的渐变群窄。总体而言，渐变群离该族中心越远往往越宽。对于这种杂交带结构有多种可能的解释，需要更多数据来区分它们。
