Little J R, Kerr F W, Sundt T M
Mayo Clin Proc. 1975 May;50(5):264-70.
The cerbral microcirculation in squirrel monkeys was studied by the carbon perfusion technique after middle cerebral artery occlusion. No filling impairment was detected with 90 minutes of ischemia, and only slight impairment was detected with 3 hours of ischemia. Severe microcirculatory obstruction was found after ischemia longer than 3 hours. The obstruction appeared to be at the capillary level and seemed partly the result of narrowing of cappillary channels by perivascular glial swelling and developing cerebral edema. The relationship between the developing microcirculatory obstruction and the distribution and severity of the neuronal alterations was studied. The results of this investigation using the same experimental model suggest that obstruction of parenchymal vessels does not play a major role in the production of an infarct in areas of acute focal ischemia.
采用大脑中动脉闭塞后碳灌注技术，对松鼠猴的脑微循环进行了研究。缺血90分钟未检测到灌注受损，缺血3小时仅检测到轻微受损。缺血超过3小时后发现严重的微循环阻塞。阻塞似乎发生在毛细血管水平，部分原因是血管周围神经胶质肿胀和脑水肿导致毛细血管通道变窄。研究了逐渐发展的微循环阻塞与神经元改变的分布及严重程度之间的关系。使用相同实验模型的这项研究结果表明，实质血管阻塞在急性局灶性缺血区域梗死的形成中不起主要作用。
