Dodson R F, Tagashira Y, Chu L W
Can J Neurol Sci. 1976 Feb;3(1):23-7. doi: 10.1017/s0317167100025956.
Ultrastructural changes in the zone of clamping of the middle cerebral artery of the squirrel monkey are described after application of a surgical clip. The experimental model utilized has been widely applied to the study of cerebral ischemia and possibly has relevance to clamps applied to the cerebral vessels during neurosurgical treatment of patients with cerebrovascular disorders. The earliest changes within the arterial wall were found in the smooth muscle (media) and accompanying fasciculi of nerves. Changes within the nerve bundles were sufficiently advances following 4 hours of vascular clipping to suggest temporary or permanent impairment of neurogenic innervation of the cerebral vessels distal to the trunk of the vessel clipped.
在应用手术夹后，描述了松鼠猴大脑中动脉夹闭区域的超微结构变化。所使用的实验模型已广泛应用于脑缺血研究，并且可能与脑血管疾病患者神经外科治疗期间应用于脑血管的夹子有关。动脉壁内最早的变化见于平滑肌（中膜）和伴随的神经束。血管夹闭4小时后，神经束内的变化已足够明显，提示被夹闭血管主干远端脑血管的神经源性支配出现暂时或永久性损伤。
