MacGregor A
City of London Migraine Clinic, 22 Charterhouse Square, London, EC1M 6DX, United Kingdom.
Headache. 1999 Oct;39(9):674-8. doi: 10.1046/j.1526-4610.1999.3909674.x.
To assess the association between estrogen replacement therapy and migraine aura.
Estrogen replacement therapy is increasingly used by perimenopausal and postmenopausal women for management of menopausal symptoms and for long-term protection against osteoporosis and arterial disease. There are few reports about the effects of estrogen replacement therapy on migraine.
Case reports were collected from women developing migraine aura related to use of estrogen replacement therapy.
Four patients who developed migraine aura associated with the use of estrogen replacement therapy are described. In all cases, reducing the dose of estrogen or changing the route of delivery was associated with loss of aura.
These findings suggest that high levels of estrogen in women using replacement therapy can trigger migraine aura.
评估雌激素替代疗法与偏头痛先兆之间的关联。
围绝经期和绝经后女性越来越多地使用雌激素替代疗法来管理更年期症状，并长期预防骨质疏松症和动脉疾病。关于雌激素替代疗法对偏头痛影响的报道较少。
收集使用雌激素替代疗法后出现偏头痛先兆的女性的病例报告。
描述了4例使用雌激素替代疗法后出现偏头痛先兆的患者。在所有病例中，减少雌激素剂量或改变给药途径均与先兆消失有关。
这些发现表明，接受替代疗法的女性体内高水平雌激素可引发偏头痛先兆。
