Ong S K, Xue S A, Molyneux E, Broadhead R L, Borgstein E, Ng M H, Griffin B E
Viral Oncology Unit, Division of Medicine, Imperial College School of Medicine at St Mary's, Norfolk Place, London W2 1PG, UK.
Trans R Soc Trop Med Hyg. 2001 Jan-Feb;95(1):93-6. doi: 10.1016/s0035-9203(01)90348-7.
High titres of antibody to Epstein-Barr virus (EBV) late genes identify individuals at risk of developing endemic Burkitt's lymphoma (eBL). Viral lytic cycle early and intermediate-early gene expression in BL is associated with a favourable tumour response to chemotherapy. Our study investigated whether serological data identifying antibody expression to zta, a viral function that activates lytic-cycle gene expression, correlate with expression of its gene in tumours, and could have prognostic value. Studies on 10 Malawian patients, with presumed BL on clinical grounds, showed good correlations, suggesting that serum antibody responses might predict treatment responsiveness. The results with 1 patient were particularly striking. When admitted in January 1998, prognosis was poor as he was unable to walk, and had tumour cells, characteristic of stage IV disease, in his bone marrow. Laboratory investigations showed particularly high levels both of serum zta antibodies and of gene expression in his tumour. Follow-up confirmed him alive 6 months after hospital discharge. Among the EBV-positive cases, 2 were ultimately diagnosed as rhabdomyosarcoma, a tumour not previously associated with this virus. The findings from this small study, if confirmed, should have value for future BL management in resource-poor parts of the world.
针对爱泼斯坦-巴尔病毒（EBV）晚期基因的高滴度抗体可识别出有发展为地方性伯基特淋巴瘤（eBL）风险的个体。BL中病毒裂解周期早期和早中期基因表达与肿瘤对化疗的良好反应相关。我们的研究调查了识别针对zta（一种激活裂解周期基因表达的病毒功能）抗体表达的血清学数据是否与其在肿瘤中的基因表达相关，以及是否具有预后价值。对10名临床诊断疑似BL的马拉维患者的研究显示出良好的相关性，表明血清抗体反应可能预测治疗反应性。1名患者的结果尤为显著。1998年1月入院时，他预后很差，无法行走，骨髓中有IV期疾病特征性的肿瘤细胞。实验室检查显示他的血清zta抗体水平和肿瘤中的基因表达水平都特别高。随访证实他出院6个月后仍存活。在EBV阳性病例中，有2例最终被诊断为横纹肌肉瘤，这是一种以前未与该病毒相关联的肿瘤。这项小型研究的结果如果得到证实，应该对世界资源匮乏地区未来的BL治疗具有价值。
