MMWR Morb Mortal Wkly Rep. 2001 Mar 16;50(10):189-90.
During the last quarter of 2000, the U.S. Public Health Service learned of a shortage of tetanus and diphtheria toxoids (Td) and tetanus toxoid (TT) resulting from decreased production of these vaccines by the two U.S. manufacturers. Previously published recommendations outlined priorities for use of the limited supply of Td and TT. The shortage was expected to be resolved by early 2001; however, on January 10, 2001, Wyeth Lederle (Pearl River, New York) announced it had stopped production of tetanus toxoid-containing products. Although a small amount of Td is produced by the University of Massachusetts for local distribution, Aventis Pasteur (Swiftwater, Pennsylvania) is now the sole nationwide distributor of Td and TT. Aventis Pasteur is shipping limited quantities of vaccine to assure a wide distribution of available doses.
2000年最后一个季度，美国公共卫生服务部门获悉，由于美国两家制造商减少了破伤风和白喉类毒素（Td）及破伤风类毒素（TT）的生产，导致这些疫苗短缺。此前发布的建议概述了有限供应的Td和TT的使用优先级。预计短缺情况将在2001年初得到解决；然而，2001年1月10日，惠氏莱德利（纽约州珍珠河）宣布已停止生产含破伤风类毒素的产品。尽管马萨诸塞大学生产少量Td用于当地分发，但安万特巴斯德（宾夕法尼亚州斯威夫特沃特）现在是Td和TT在全国的唯一经销商。安万特巴斯德正在运送有限数量的疫苗，以确保现有剂量能广泛分发。
