Induction of hepatitis B virus-specific cytotoxic T lymphocytes response in vivo by filamentous phage display vaccine.

作者信息

Wan Y, Wu Y, Bian J, Wang X Z, Zhou W, Jia Z C, Tan Y, Zhou L

机构信息

The Institute of Immunology, The Third Military Medicine University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, People's Republic of China.

出版信息

Vaccine. 2001 Apr 6;19(20-22):2918-23. doi: 10.1016/s0264-410x(00)00561-2.

The ability of inducing MHC class I restricted cytotoxic T lymphocytes response in vivo via recombinant filamentous phage was investigated. The recombinant filamentous phage particles that displayed the Hepatitis B virus epitope S(28--39) were injected into BALB/c (H-2d) mice without adjuvants. A MHC class I restricted HBs specific CTL response was found 8 days after injection. The potentiality of using the recombinant filamentous phage as anti-virus vaccine was discussed.