聚酮化合物和非核糖体肽的组合生物合成。
Combinatorial biosynthesis of polyketides and nonribosomal peptides.
作者信息
Staunton J, Wilkinson B
机构信息
University Chemical Laboratory and Cambridge Centre for Molecular Recognition, Cambridge, UK.
出版信息
Curr Opin Chem Biol. 2001 Apr;5(2):159-64. doi: 10.1016/s1367-5931(00)00185-x.
Abstract
The engineering of polyketide biosynthesis has begun to provide robust targeted libraries for screening against pharmaceutically relevant targets. New technologies that offer methodology for the rapid generation of more structurally diverse libraries have now been demonstrated.
摘要
聚酮生物合成工程已开始为针对药学相关靶点的筛选提供丰富的靶向文库。现已证明了能够为快速生成结构更多样化文库提供方法的新技术。
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