Bandyopadhyay Arpan A, Khetan Anurag, Malmberg Li-Hong, Zhou Weichang, Hu Wei-Shou
Department of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Avenue SE, Minneapolis, MN, 55455-0132, USA.
Biological Process Development, Bristol Myers Squibb, 521 NJ-173, Bloomsbury, NJ, 08804, USA.
J Ind Microbiol Biotechnol. 2017 May;44(4-5):785-797. doi: 10.1007/s10295-017-1913-4. Epub 2017 Feb 9.
The emergence of natural products and industrial microbiology nearly eight decades ago propelled an era of bioprocess innovation. Half a century later, recombinant protein technology spurred the tremendous growth of biologics and added mammalian cells to the forefront of industrial producing cells in terms of the value of products generated. This review highlights the process technology of natural products and protein biologics. Despite the separation in time, there is a remarkable similarity in their progression. As the new generation of therapeutics for gene and cell therapy emerges, its process technology development can take inspiration from that of natural products and biologics.
近八十年前天然产物和工业微生物学的出现推动了生物工艺创新的时代。半个世纪后，重组蛋白技术推动了生物制品的巨大发展，并使哺乳动物细胞在产生产品的价值方面跃居工业生产细胞的前沿。本文综述了天然产物和蛋白质生物制品的工艺技术。尽管时间上有间隔，但它们的发展有显著的相似性。随着用于基因和细胞治疗的新一代疗法的出现，其工艺技术的发展可以从天然产物和生物制品的工艺技术中获得启发。
