Valdez T A, McMillan K, Shapshay S M
Department of Otolaryngology--Head and Neck Surgery, Tufts University School of Medicine, New England Medical Center, Boston, MA 02111, USA.
Otolaryngol Head Neck Surg. 2001 Apr;124(4):421-5. doi: 10.1067/mhn.2001.113944.
Microvascular targeting with the 585- nm pulsed dye laser (PDL) may provide a new form of therapy to control symptoms caused by recurrent respiratory papillomatosis (RRP).
Ten patients with RRP underwent 13 procedures under general anesthesia with the 585-nm PDL. A micromanipulator (11 procedures) and a flexible nasolaryngoscope (2 procedures) were used to deliver the laser pulses. Patients were followed postoperatively according to protocol.
Clinical examination revealed regression of papillomas in all patients. Seven patients had complete regression after PDL surgery, and 2 patients had partial response to treatment. One patient was lost to follow-up. No complications were present during this prospective nonrandomized pilot study.
Patients treated with PDL experienced regression of their papillomas. PDL may provide patients with RRP with an alternative treatment without the risks associated with CO(2) laser surgery. This procedure also has potential to be delivered on an outpatient basis with flexible fiberoptic laryngoscopes.
使用585纳米脉冲染料激光(PDL)进行微血管靶向治疗可能为控制复发性呼吸道乳头状瘤病(RRP)引起的症状提供一种新的治疗方式。
10例RRP患者在全身麻醉下接受了13次585纳米PDL治疗。使用显微操作器(11次治疗)和可弯曲鼻咽喉镜(2次治疗)来发射激光脉冲。术后按照方案对患者进行随访。
临床检查显示所有患者的乳头状瘤均有消退。7例患者在PDL手术后完全消退,2例患者对治疗有部分反应。1例患者失访。在这项前瞻性非随机试验研究中未出现并发症。
接受PDL治疗的患者乳头状瘤出现消退。PDL可为RRP患者提供一种替代治疗方法,且无与二氧化碳激光手术相关的风险。该治疗方法还有可能通过可弯曲纤维喉镜在门诊进行。