Franco Ramon A
Department of Otology and Laryngology, Harvard Medical School, Division of Laryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA.
Otolaryngol Head Neck Surg. 2007 Jun;136(6):882-7. doi: 10.1016/j.otohns.2007.01.026.
To evaluate the safety and efficacy of aminolevulinic acid photodynamic therapy (ALA-PDT) with the 585 nm pulsed dye laser.
A 5-year prospective study was performed with 12 male patients with keratosis. Twenty percent ALA was sprayed into the larynx and activated with the 585 nm pulsed dye laser (PDL). Of the 12 patients, four were not included (one lost to follow-up, two developed cancer, one papillomatosis), which reduced the number to eight. Twenty-eight procedures were performed in these eight patients; 18 (64%) procedures were performed in the clinic setting.
There was a 78% reduction (range, 10% to 100%) in the keratosis. No major side effects were noted. Mean follow-up was 34.5 months (range, 12 to 50 months). There were no statistical differences between the outpatient and operating room treatments.
ALA-PDL PDT is effective and safe in treating laryngeal keratosis in the awake clinic setting and reduces morbidity without sacrificing treatment efficacy.
评估采用585纳米脉冲染料激光进行氨基乙酰丙酸光动力疗法（ALA-PDT）的安全性和有效性。
对12例角化病男性患者进行了为期5年的前瞻性研究。将20%的ALA喷入喉部，并用585纳米脉冲染料激光（PDL）激活。12例患者中，4例未纳入研究（1例失访，2例患癌，1例患乳头状瘤病），研究对象减少至8例。这8例患者共接受了28次治疗；其中18次（64%）治疗在门诊进行。
角化病减少了78%（范围为10%至100%）。未观察到严重副作用。平均随访时间为34.5个月（范围为12至50个月）。门诊治疗和手术室治疗之间无统计学差异。
ALA-PDL PDT在清醒状态下的门诊环境中治疗喉角化病有效且安全，可降低发病率且不影响治疗效果。
