Wexler D B, Berger G, Derowe A, Ophir D
Department of Otolaryngology--Head and Neck Surgery, Meir General Hospital, Sapir Medical Center, Kfar Saba, Israel.
Otolaryngol Head Neck Surg. 2001 Apr;124(4):459-63. doi: 10.1067/mhn.2001.114793.
In this study we sought to define the histologic changes produced by laser treatment of inferior turbinates.
Eight inferior turbinates with prior laser treatment (mean, 26.8 months) were analyzed by light microscopy after turbinectomy for relief of refractory nasal obstruction. Histologic findings were compared with those of a group of 8 hypertrophic inferior turbinates that had no previous laser surgery.
Laser-treated areas of the inferior turbinates demonstrated a histologically bland appearance, with marked diminution of seromucinous glands and relative preponderance of connective tissue matrix. Prominence of venous sinusoids was also significantly reduced in the laser-treated areas. Surface epithelium including goblet cells was reconstituted over the areas of laser application.
Clinical laser surgery of the inferior turbinate produces striking long-term histologic changes.
The data suggest a differential response of turbinate histologic components to application of laser energy, with the glandular component being particularly sensitive. Further correlative study is needed to clarify the clinical significance of laser-induced histologic changes in inferior turbinates.
在本研究中，我们试图明确激光治疗下鼻甲所产生的组织学变化。
对8个先前接受过激光治疗（平均26.8个月）的下鼻甲进行分析，在鼻甲切除术后通过光学显微镜检查以缓解难治性鼻阻塞。将组织学结果与一组8个未曾接受过激光手术的肥厚性下鼻甲的结果进行比较。
下鼻甲的激光治疗区域在组织学上呈现出平淡的外观，浆液黏液性腺明显减少，结缔组织基质相对占优势。激光治疗区域的静脉血窦也明显减少。包括杯状细胞在内的表面上皮在激光照射区域重新形成。
下鼻甲的临床激光手术会产生显著的长期组织学变化。
数据表明下鼻甲组织学成分对激光能量的应用有不同反应，腺性成分尤其敏感。需要进一步的相关研究来阐明激光诱导的下鼻甲组织学变化的临床意义。
