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钬激光与半导体激光治疗下鼻甲增生的长期疗效比较

Comparison of long term results after Ho:YAG and diode laser treatment of hyperplastic inferior nasal turbinates.

作者信息

Sroka Ronald, Janda Philip, Killian Tina, Vaz Francis, Betz Christian S, Leunig Andreas

机构信息

Laser-Research Laboratory at the LIFE-Center, Ludwig-Maximilians University, 81377 Munich, Germany.

出版信息

Lasers Surg Med. 2007 Apr;39(4):324-31. doi: 10.1002/lsm.20479.

Abstract

BACKGROUND AND OBJECTIVE

Various laser systems have been used to reduce the volume of hyperplastic inferior nasal turbinates during the last 25 years. Although there are many studies reporting the clinical results immediately after laser treatment, there are only a few describing long-term results. Therefore, a clinical study was performed to assess and to compare the long-term outcome of both endonasal Ho:YAG and endonasal diode laser-assisted turbinate surgery.

STUDY DESIGN/MATERIALS AND METHODS: In the first treatment group, a total of 80 patients (allergic rhinitis (46%) and vasomotor rhinitis (54%)) suffering from nasal obstruction due to hyperplastic inferior nasal turbinates were treated by a pulsed Ho:YAG laser emitting light at a wavelength of lambda = 2,100 nm (pulse energy: 0.8-1.2 J/pulse, repetition rate: 4-8 Hz) under local anesthesia. In the second group, an additional 113 patients (allergic rhinitis (52%) and vasomotor rhinitis (48%)) were treated by means of a continuous wave GaAlAs-diode laser emitting light at a wavelength of lambda = 940 nm (power: 8-10 W). The treatment time was 3-10 minutes per turbinate and the nasal cavities were left unpacked following the procedure. The study concerning long-term effects was conducted using a standardized questionnaire, allergy test, and rhinomanometry within a follow-up period of 6 month and after 3 years. All patients were refractory to conservative medical treatment prior to laser treatment.

RESULTS

Three years after laser treatment, a subjective improvement of nasal airflow had been described by the patients in 67.5% after Ho:YAG- and in 74.4% after diode laser treatment. Rhinomanometry revealed a significant improvement of the nasal airflow at both 6 months and 3 years after the laser treatment as compared to the preoperative data. Side effects like nasal dryness and pain were rare (<5%) and occurred only during the first weeks after the intervention. After diode laser treatment, patients showed nasal obstruction due to postoperative edema and nasal crusting during the first 3-4 weeks, whereas patients from the Ho:YAG laser group described these symptoms only for a period of 1-2 weeks.

CONCLUSION

Both Ho:YAG- and diode laser treatment, which are performed as an outpatient procedure under local anesthesia, show promising long-term results. It has therefore, developed to become a time and cost-effective treatment modality in endonasal laser surgery at our institution. While short-term differences concerning the healing process after Ho:YAG- compared to diode-laser treatment could be ascertained according to the subjective and objective evaluation, no significant long-term differences between the two investigated groups could be observed.

摘要

背景与目的

在过去25年中,各种激光系统已被用于减少增生性下鼻甲的体积。尽管有许多研究报告了激光治疗后的即时临床结果,但描述长期结果的研究却很少。因此,进行了一项临床研究,以评估和比较鼻内钬激光和鼻内半导体激光辅助下鼻甲手术的长期疗效。

研究设计/材料与方法:在第一治疗组中,共有80例因增生性下鼻甲导致鼻塞的患者(变应性鼻炎46%,血管运动性鼻炎54%)在局部麻醉下接受波长为λ = 2100nm的脉冲钬激光治疗(脉冲能量:0.8 - 1.2J/脉冲,重复频率:4 - 8Hz)。在第二组中,另外113例患者(变应性鼻炎52%,血管运动性鼻炎48%)接受波长为λ = 940nm的连续波砷化镓铝半导体激光治疗(功率:8 - 10W)。每个鼻甲的治疗时间为3 - 10分钟,术后鼻腔不填塞。在6个月和3年的随访期内,使用标准化问卷、变应原检测和鼻阻力测量进行长期疗效研究。所有患者在激光治疗前对保守药物治疗均无效。

结果

激光治疗3年后,钬激光治疗组67.5%的患者自述鼻气流主观改善,半导体激光治疗组为74.4%。鼻阻力测量显示,与术前数据相比,激光治疗后6个月和3年鼻气流均有显著改善。鼻干和疼痛等副作用很少见(<5%),仅在干预后的前几周出现。半导体激光治疗后,患者在术后前3 - 4周因术后水肿和鼻痂形成出现鼻塞,而钬激光治疗组患者仅在1 - 2周内出现这些症状。

结论

钬激光和半导体激光治疗均在局部麻醉下作为门诊手术进行,显示出良好的长期疗效。因此,在我们机构的鼻内激光手术中,它已发展成为一种省时且经济有效的治疗方式。根据主观和客观评估,可以确定钬激光治疗与半导体激光治疗在愈合过程中的短期差异,但在两个研究组之间未观察到显著的长期差异。

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