Layton W, Sutherland J M
Med J Aust. 1975 Jan 18;1(3):73-7. doi: 10.5694/j.1326-5377.1975.tb111236.x.
A hypothesis is presented and evidence is adduced to show that high-risk areas of multiple sclerosis are related to the ability of the soils of the locality to obtain and fix molybdenum perferentially to copper. Soil conditons capable of such partition are known to be present characteristically in cool temperate zones and are significantly present in acid podsols of these regions. On the other hand, under tropical and subtropical conditions, molybdenum is normally highly mobile and leached from the environment. Copper may also be leached but can accumulate in caliche deposits. This hypothesis is notopposed to the theory of a viral aetology of multiple sclerosis, but rather seeks to show that certain individuals, if exposed to trace element imbalance at a critical period in life, may be rendered susceptible to a slow virus infection.
本文提出了一种假说，并列举证据表明，多发性硬化症的高危地区与当地土壤优先获取和固定钼而非铜的能力有关。已知能够进行这种分配的土壤条件典型地存在于凉爽温带地区，并且在这些地区的酸性灰化土中显著存在。另一方面，在热带和亚热带条件下，钼通常具有高度的流动性并从环境中淋失。铜也可能被淋失，但会在钙积层中积累。这一假说并不反对多发性硬化症病毒病因学理论，而是试图表明，某些个体如果在生命的关键时期暴露于微量元素失衡的环境中，可能会易患慢病毒感染。
