mRNA定位：移动中的信息

mRNA localization: message on the move.

作者信息

Jansen R P

机构信息

Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany.

出版信息

Nat Rev Mol Cell Biol. 2001 Apr;2(4):247-56. doi: 10.1038/35067016.

DOI:10.1038/35067016

PMID:11283722

Abstract

Cytoplasmic messenger RNA localization is a key post-transcriptional mechanism of establishing spatially restricted protein synthesis. The characterization of cis-acting signals within localized mRNAs, and the identification of trans-acting factors that recognize these signals, has opened avenues towards identifying the machinery and mechanisms involved in mRNA transport and localization.

摘要

细胞质信使核糖核酸定位是建立空间受限蛋白质合成的关键转录后机制。对定位信使核糖核酸内顺式作用信号的表征以及对识别这些信号的反式作用因子的鉴定，为识别参与信使核糖核酸运输和定位的机制和机器开辟了道路。