Kölmel K F, Lippold A, Kulle B, Veltmaat S, Stoltenberg M, Seebacher C
Universitäts-Hautklinik Göttingen, von-Siebold-Strasse 3, 37075 Göttingen.
Hautarzt. 2001 Mar;52(3):211-8. doi: 10.1007/s001050051292.
The final goals of malignant melanoma prevention are lowering incidence and mortality. We assessed the parameter "survival" for both men and women as the beginning point for future gender-directed prevention campaigns. We compared the periods 1972-1980, 1981-1988, 1989-1996, and determined the influence of age and of Breslow' tumor thickness on survival.
PATIENTS/METHODS: We had sufficient follow-up on 10.433 patients. We calculated survival curves according to Kaplan-Meier and defined differences by the logrank test.
At all periods of time, survival of women was higher compared with men, but with no impressive changes over time. This was especially true for younger men. The most important prognostic factor was the Breslow tumor thickness. Within all periods of time, its median was higher in men. A trend downwards for both genders could be observed with higher influence on survival in men.
Our findings justify melanoma prevention campaigns addressed to men. Evaluation of such campaigns has to take into account an already existing upwards trend for male survival, which exceeds that of female survival.
恶性黑色素瘤预防的最终目标是降低发病率和死亡率。我们将男性和女性的“生存率”参数作为未来针对性别预防活动的起点进行评估。我们比较了1972 - 1980年、1981 - 1988年、1989 - 1996年这几个时间段，并确定了年龄和布雷斯洛肿瘤厚度对生存率的影响。
患者/方法：我们对10433例患者进行了充分的随访。我们根据卡普兰 - 迈耶方法计算生存曲线，并通过对数秩检验确定差异。
在所有时间段内，女性的生存率均高于男性，但随时间推移无明显变化。年轻男性尤其如此。最重要的预后因素是布雷斯洛肿瘤厚度。在所有时间段内，男性的肿瘤厚度中位数更高。随着肿瘤厚度增加，两性的生存率均呈下降趋势，且对男性生存率的影响更大。
我们的研究结果证明了针对男性的黑色素瘤预防活动的合理性。对此类活动的评估必须考虑到男性生存率已经存在的上升趋势，这一趋势超过了女性生存率的上升趋势。
