Tersmette A C, Coebergh J W, Casparie-van Velsen I J, Ruiter D J, van der Rhee H J, Welvaart K
Comprehensive Cancer Centre West (IKW), Leiden, The Netherlands.
Eur J Cancer Prev. 1996 Feb;5(1):69-74.
The Breslow or tumour thickness is the most important prognostic factor for survival from cutaneous melanoma. We studied the occurrence of melanoma in relation to tumour thickness and subsite in The Netherlands. Data on all newly diagnosed invasive cutaneous melanomas in the Netherlands Cancer Registry in 1989 and 1990 were used to estimate age and sex-specific incidence rates according to site and depth of tumour invasion. The incidence among women (9.5 per 100,000 person-years) was relatively high compared with other European countries. The predominant site was the trunk among men and the leg among women. After age 70, one-third of the melanomas were observed in the head and neck region. According to data from PALGA, the national computerized archive of Dutch pathology laboratories, 37% of the men and 29% of the women had a melanoma > 1.5 mm thick. Among persons younger than age 60, 26% had a melanoma > 1.5 mm thick, compared with 44% among those 60 years and over. In both registries the absolute and relative risks for a thicker melanoma increased with age, particularly for men. In The Netherlands, preventive measures for population groups with thicker melanomas should be targeted towards men and elderly persons.
布雷斯洛厚度或肿瘤厚度是皮肤黑色素瘤生存的最重要预后因素。我们研究了荷兰黑色素瘤的发生与肿瘤厚度及亚部位的关系。利用荷兰癌症登记处1989年和1990年所有新诊断的侵袭性皮肤黑色素瘤的数据，根据肿瘤侵袭的部位和深度来估计年龄和性别特异性发病率。与其他欧洲国家相比，女性的发病率（每10万人年9.5例）相对较高。男性的主要发病部位是躯干，女性是腿部。70岁以后，三分之一的黑色素瘤发生在头颈部区域。根据荷兰病理实验室的全国计算机化档案PALGA的数据，37%的男性和29%的女性患有厚度大于1.5毫米的黑色素瘤。在60岁以下的人群中，26%患有厚度大于1.5毫米的黑色素瘤，而60岁及以上人群中这一比例为44%。在这两个登记处，黑色素瘤厚度增加的绝对风险和相对风险均随年龄增长而增加，男性尤为明显。在荷兰，针对黑色素瘤厚度较大人群的预防措施应针对男性和老年人。
