Saviola G, Santoro L
Servizio Aggregato di Reumatologia, Fondazione Salvatore Maugeri I.R.C.C.S., Istituto Scientifico di Castel Goffredo, Via Ospedale 36, 46042 Castel Goffredo, MN, Italy.
G Ital Med Lav Ergon. 2000 Oct-Dec;22(4):328-31.
29 patients suffering from erosive osteoarthritis of the hands (26 women with a mean age of 61.47 years and 3 men with a mean age of 53.3 years) were treated during painful episodes with cyclical intravenous clodronate (300 mg for slow infusion for 7 days). We administered 73 cycles after which the pain, evaluated by VAS' score, decreased from 5.63 +/- 2.14 to 2.93 +/- 1.95 (p = 0.0001); the pain reduction lasted for a mean of 88.33 days. In 16 out of those 73 cycles were measured also: the strength of the hands (mmHg) which increased, on the right from 169.38 +/- 75.85 to 190.31 +/- 81.76, on the left from 180.56 +/- 68.27 to 196.11 +/- 85.55 (p = n.s.); the number of painful joints which decreased from 4.75 +/- 2.52 to 2.56 +/- 1.93 (p = 0.0011); the number of swollen joints which decreased from 3.07 +/- 2.69 to 2.67 +/- 2.61 (p = n.s). These data prove the efficacy of the clodronate in treating painful episodes of erosive osteoarthritis and suggest that bisphoshonates could play an important role in the rehabilitation of this disease.
29例手部侵蚀性骨关节炎患者（26例女性，平均年龄61.47岁，3例男性，平均年龄53.3岁）在疼痛发作期接受周期性静脉注射氯膦酸盐治疗（300mg缓慢输注7天）。我们共进行了73个疗程，之后通过视觉模拟评分法（VAS）评估的疼痛程度从5.63±2.14降至2.93±1.95（p = 0.0001）；疼痛缓解平均持续88.33天。在这73个疗程中的16个疗程还测量了：手部力量（mmHg），右侧从169.38±75.85增加到190.31±81.76，左侧从180.56±68.27增加到196.11±85.55（p =无统计学意义）；疼痛关节数量从4.75±2.52减少到2.56±1.93（p = 0.0011）；肿胀关节数量从3.07±2.69减少到2.67±2.61（p =无统计学意义）。这些数据证明了氯膦酸盐在治疗侵蚀性骨关节炎疼痛发作方面的疗效，并表明双膦酸盐在这种疾病的康复中可能发挥重要作用。
