de Vries P L
Spatie, Centrum voor Geestelijke Gezondheidszorg, afd. Sociale Psychiatrie, Postbus 928, 7301 BD Apeldoorn.
Ned Tijdschr Geneeskd. 2001 Mar 17;145(11):539-40.
A 40-year-old woman with a schizoaffective disorder was, inter alia, receiving lithium carbonate. During a simultaneous treatment with trimethoprim, she experienced symptoms of nausea, a feeling of malaise, concentration problems, trembling, an uncertain gait, diarrhoea and muscle spasms, without fever. The lithium level appeared to be elevated. The only cause of the intoxication indicated was the simultaneous use of trimethoprim. Following clinical rehydration, the patient made a good recovery. Trimethoprim has the same effect on the kidney as amiloride, a potassium-sparing diuretic, for which it is known that its combined use with lithium can result in an elevated lithium level.
一名患有分裂情感性障碍的40岁女性，除其他治疗外，正在服用碳酸锂。在同时接受甲氧苄啶治疗期间，她出现了恶心、不适、注意力不集中、颤抖、步态不稳、腹泻和肌肉痉挛等症状，但无发热。锂水平似乎升高了。唯一表明的中毒原因是同时使用了甲氧苄啶。经过临床补液后，患者恢复良好。甲氧苄啶对肾脏的作用与保钾利尿剂阿米洛利相同，已知其与锂联合使用会导致锂水平升高。
