Porto Fábio H G, Leite Marco A A, Fontenelle Leonardo F, Marrocos Rogério P, Szczerback Natália F, de Freitas Marcos R G
Federal Fluminense University, Miguel de Frias 245, bl 3 apt 601, Niterói, Rio de Janeiro, 24220-005, Brazil.
J Neurol Sci. 2009 Feb 15;277(1-2):172-3. doi: 10.1016/j.jns.2008.10.010. Epub 2008 Nov 30.
In this article, we report the case history of a 44-year-old female patient with bipolar disorder who developed the so-called Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT). A detailed description of our patient's neurologic status is provided at baseline (i.e. during lithium intoxication) and after one year of follow-up, confirming the persistency of cerebellar signs and symptoms. Although rare, our report - which shows a severe and disabling form of SILENT - underscores the need to perform a strict control of the putative risk factors argued to be associated with the development of this syndrome. In our case, the presence of fever and the administration of multiple doses of antipsychotics may have contributed to the poor outcome exhibited by the patient.
在本文中，我们报告了一名44岁双相情感障碍女性患者出现所谓不可逆锂所致神经毒性综合征（SILENT）的病例史。在基线时（即锂中毒期间）和随访一年后，对我们患者的神经状态进行了详细描述，证实了小脑体征和症状的持续性。尽管罕见，但我们的报告——显示了一种严重且致残的SILENT形式——强调了对被认为与该综合征发展相关的假定风险因素进行严格控制的必要性。在我们的病例中，发热的存在以及多次使用抗精神病药物可能导致了患者出现不良结局。
