Pandit A A, Phulpagar M D
Department of Pathology, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Parel, Mumbai, India.
Acta Cytol. 2001 Mar-Apr;45(2):173-9. doi: 10.1159/000327273.
To investigate worrisome histologic alterations following fine needle aspiration (FNA) of the thyroid (WHAFFT).
Of 1,890 FNA thyroid cases, 265 underwent surgical excision. The histologic sections of these cases were studied for WHAFFT lesions. Thirty control cases were also studied.
WHAFFT lesions were present in 38.49% of cases. Acute lesions were seen in 30 and chronic in 72 cases. Control cases did not show WHAFFT lesions. The common lesions were hemorrhage and fibrosis. Worrisome lesions, like nuclear atypia, vascular changes, capsular pseudoinvasion and metaplasia, were present in 32 (12.07%) cases.
Considering the large number of FNAs and reduction in the number of thyroid excisions, the advantages of FNA are manifold as compared to the few diagnostic problems. Misdiagnosis can be avoided with awareness of WHAFFT lesions.
研究甲状腺细针穿刺活检（FNA）后令人担忧的组织学改变（WHAFFT）。
在1890例甲状腺FNA病例中，265例接受了手术切除。对这些病例的组织学切片进行WHAFFT病变研究。还研究了30例对照病例。
38.49%的病例存在WHAFFT病变。30例可见急性病变，72例可见慢性病变。对照病例未显示WHAFFT病变。常见病变为出血和纤维化。32例（12.07%）病例存在令人担忧的病变，如核异型性、血管改变、包膜假浸润和化生。
考虑到大量的FNA检查以及甲状腺切除数量的减少，与少数诊断问题相比，FNA的优势是多方面的。认识到WHAFFT病变可避免误诊。
