甲状旁腺细针穿刺后令人担忧的组织学改变。
Worrisome histologic alterations following fine-needle aspiration of the parathyroid.
作者信息
Alwaheeb S, Rambaldini G, Boerner S, Coiré C, Fiser J, Asa S L
机构信息
Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network and Toronto Medical Laboratories, Toronto, Canada.
出版信息
J Clin Pathol. 2006 Oct;59(10):1094-6. doi: 10.1136/jcp.2005.029017.
Fine-needle aspiration (FNA) is a procedure that is increasingly being performed. Artefacts occurring after FNA are reported to complicate the histological analysis of the tissue, mainly in the thyroid; WHAFFT (worrisome histologic alterations following FNA of thyroid) is well documented in the literature. The case of a male patient with hypercalcaemia who was subsequently found to have a nodule in the thyroid gland is reported here. He underwent FNA, followed by a total thyroidectomy and parathyroidectomy. The abnormality in the parathyroid gland showed worrisome histological changes that were suspicious of a malignant lesion, resembling the changes seen in the thyroid gland after FNA. Parathyroid cells were identified by a review of the previous FNA. The concept of WHAFFT, which can mimic the features of malignancy in the parathyroid gland, is therefore introduced.
细针穿刺抽吸术（FNA）是一种越来越常被施行的操作。据报道，FNA后出现的人为假象会使组织的组织学分析复杂化，主要是在甲状腺；FNA后甲状腺出现令人担忧的组织学改变（WHAFFT）在文献中有充分记载。本文报告了一例男性高钙血症患者，随后发现其甲状腺有一个结节。他接受了FNA，随后进行了甲状腺全切除术和甲状旁腺切除术。甲状旁腺的异常显示出令人担忧的组织学变化，怀疑是恶性病变，类似于FNA后甲状腺所见的变化。通过回顾之前的FNA确定了甲状旁腺细胞。因此引入了WHAFFT的概念，它可以模拟甲状旁腺恶性肿瘤的特征。
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