Ivanova M, Spassova P, Michailova A, Naumova E
Division of Clinical and Transplantation Immunology, Medical University, Sofia, Bulgaria.
Tissue Antigens. 2001 Mar;57(3):208-15. doi: 10.1034/j.1399-0039.2001.057003208.x.
In this study we present for the first time HLA class I allele and haplotype frequencies at DNA level in the Bulgarian population. HLA class I profile of Bulgarians has been compared to other European and Mediterranean populations of common historical background in order to clarify more precisely the origin of our population. Genetic distances, phylogenetic trees and correspondence analyses show that the Bulgarian population is more closely related to the Italian, the Mediterranean, the Armenian and the Romanian population than to the other East and West European population. This is further supported by the analysis of HLA class I haplotypes in Bulgarians. Most of them are also common in Europe. However their frequency pattern in Bulgarians is similar to the South European populations. The presence of some rare alleles and haplotypes indicated Asian genetic inflow. On the basis of HLA class I profile and supported by historical and anthropological data, we suggest that the Bulgarian population is characterized by the features of the Southern European anthropological type with some influence of other groups such as Asians, Turks, Armenians. Migrations and assimilation of many different ethnic groups are the major factor determining the genetic diversity of our population.
在本研究中，我们首次呈现了保加利亚人群DNA水平上的HLA I类等位基因和单倍型频率。已将保加利亚人的HLA I类图谱与具有共同历史背景的其他欧洲和地中海人群进行比较，以便更精确地阐明我们人群的起源。遗传距离、系统发育树和对应分析表明，保加利亚人群与意大利、地中海、亚美尼亚和罗马尼亚人群的关系比与其他东欧和西欧人群更为密切。保加利亚人HLA I类单倍型的分析进一步支持了这一点。其中大多数在欧洲也很常见。然而，它们在保加利亚人中的频率模式与南欧人群相似。一些罕见等位基因和单倍型的存在表明有亚洲基因流入。基于HLA I类图谱，并得到历史和人类学数据的支持，我们认为保加利亚人群具有南欧人类学类型的特征，并受到亚洲人、土耳其人、亚美尼亚人等其他群体的一些影响。许多不同种族群体的迁移和同化是决定我们人群遗传多样性的主要因素。
