Valenzuela R, Govindarajan S, Tubbs R, Deodhar S, Bukowski R
Am J Clin Pathol. 1979 Aug;72(2):246-50. doi: 10.1093/ajcp/72.2.246.
A case of IgD myeloma in a 48-year-old Caucasian man is reported. The unusual features of this case included the absence of osteolytic lesions by x-ray, absence of anemia, absence of monoclonal spike on serum electrophoresis, association of kappa light chains, absence of Bence Jones proteinemia and Bence Jones proteinuria, and a remarkable, temporary clinical response to therapy. Immunoelectrophoresis of whole serum yielded a pattern consistent with IgD kappa monoclonal gammopathy. Immunoelectrophoresis of a pure serum IgD preparation, previously separated by gel chromatography (Sephadex G-200), revealed definitive information about an IgD kappa monoclonal gammopathy. Immunomicroscopic examination of bonemarrow smears showed the presence of delta and kappa chains only in the cytoplasm of plasma cells.
报告了一例48岁白种男性的IgD骨髓瘤病例。该病例的不寻常特征包括：X线检查无溶骨性病变、无贫血、血清电泳无单克隆峰、κ轻链相关、无本-周蛋白血症和本-周蛋白尿，以及对治疗有显著的、暂时的临床反应。全血清免疫电泳结果与IgD κ单克隆丙种球蛋白病一致。先前通过凝胶色谱法（Sephadex G - 200）分离的纯血清IgD制剂的免疫电泳显示了关于IgD κ单克隆丙种球蛋白病的确切信息。骨髓涂片的免疫显微镜检查显示仅在浆细胞的细胞质中存在δ链和κ链。
