Manzke H, Mau G
Monatsschr Kinderheilkd (1902). 1975 Mar;123(3):124-7.
Nevus flammeus (teleangiectaticus) is the most common variety of congenital nevus. Among 3961 infants checked at the ages of 3--7 days and again at 6 weeks 42% showed nevi flammei mediales in the nape and/or in the eyelids and glabella. The mothers of the infants presenting with n.fl. tended to be overweight, to have circulatory distrubances and prolonged duration of laor. The infants with n.fl. frequently had concomittant edema, navel hernia and minor degenerative stigmata. However malformations did not occur more commonly. This investigation suggests that exogenous factors such as diseases during pregnancy, intake of drugs and difficulties in delivery do not influence the genesis of n.fl. Only constitutional factors could be correlated with the incidence of n.fl. Since there was a higher frequency in female than in male infants and a lower frequency in premature than in term newborns it may be that hormonal inffluences increase the incidence of n.fl., too. These results were obtained from the prospective study: Schwanger-schaftsverlauf und Kindesentwickling (DFG).
鲜红斑痣（毛细血管扩张性）是最常见的先天性痣。在3961名3至7天及6周时再次接受检查的婴儿中，42%在颈背和/或眼睑及眉间有内侧鲜红斑痣。出现鲜红斑痣的婴儿的母亲往往超重，有循环系统紊乱和产程延长的情况。有鲜红斑痣的婴儿经常伴有水肿、脐疝和轻微的发育缺陷体征。然而，畸形的发生并不更常见。这项研究表明，诸如孕期疾病、药物摄入和分娩困难等外部因素不会影响鲜红斑痣的发生。只有体质因素可能与鲜红斑痣的发病率相关。由于女婴的发病率高于男婴，早产儿的发病率低于足月儿，可能激素影响也会增加鲜红斑痣的发病率。这些结果来自前瞻性研究：Schwanger-schaftsverlauf und Kindesentwickling（德国研究基金会）。
