Simon C, Krüger H
Monatsschr Kinderheilkd (1902). 1975 Mar;123(3):97-9.
In Schleswig-Holstein 271 children (131 boys, 140 girls) were treated for tuberculosis between january 1968 and June 1973; 84% were aged 5--14 years, 14% between 1--4 years and 29% between 0--1 year. Each year, nearly the same number of infections occurred in the various districts of the country. In 246 children a primary form of tuberculosis was diagnosed (in 11 cases with pleurisy). 11 patients tuberculous meningitis, 3 patients miliary tuberculosis and 5 patients another form of the disease, 18 of 271 patients (7%) had been vaccinated against tuberculosis as newborns; in 4 of these children tubercle bacilli could be isolated. BCG vaccination had been done 8--12 years before disease in 11 cases and 1--5 years before disease in 7 cases. None of these vaccinated children had a hematogenous tuberculosis or died. Of the non-vaccinated children two patients had meninogencephalitis and died. The other children were cured by chemotherapy, 12 children by additional surgery. The morbidity of tuberculosis in Schleswig-Holstein was 7--10 per 100000 children. Therefore, further BCG vaccination, chemoprophylaxis or preventive chemotherapy seems necessary. Early recognition of tuberculosis in old persons may be of practical value to prevent infections in children.
1968年1月至1973年6月期间，石勒苏益格－荷尔斯泰因州有271名儿童（131名男孩，140名女孩）接受了结核病治疗；84%的患儿年龄在5至14岁之间，14%在1至4岁之间，2%在0至1岁之间。该国各地区每年发生的感染病例数几乎相同。246名儿童被诊断为原发性结核病（11例伴有胸膜炎）。11例患结核性脑膜炎，3例患粟粒性结核病，5例患其他形式的疾病，271例患者中有18例（7%）在新生儿期接种过卡介苗；其中4名儿童可分离出结核杆菌。11例在发病前8至12年接种卡介苗，7例在发病前1至5年接种。这些接种过疫苗的儿童均未发生血行播散性结核病，也无死亡病例。未接种疫苗的儿童中有2例患脑膜脑炎并死亡。其他儿童通过化疗治愈，12名儿童还接受了额外的手术治疗。石勒苏益格－荷尔斯泰因州的儿童结核病发病率为每10万人7至10例。因此，进一步接种卡介苗、化学预防或预防性化疗似乎很有必要。早期发现老年人的结核病可能对预防儿童感染具有实际意义。
