Cribier B, Scrivener Y, Grosshans E
Laboratoire d'Histopathologie Cutanée, Clinique Dermatologique des Hôpitaux Universitaires, Strasbourg, France.
Am J Dermatopathol. 2001 Apr;23(2):99-103. doi: 10.1097/00000372-200104000-00003.
Molluscum contagiosum (MC) is rarely associated with other skin diseases, especially cutaneous neoplasms. Such associations are exceptional and of unknown frequency. The aim of this study was to record the histologic variants and frequency of associated lesions in a large series of consecutive MC cases. We reviewed 578 MC cases from the Laboratory of Dermatopathology of the University Hospitals of Strasbourg, France (1959-1999). The locations of MC were as follows: head and neck (34.7%), trunk (27.1%), lower limbs (20.7%), upper limbs (8.7%), and genitalia (3.8%). Molluscum contagiosum occurred more often in female patients (56.7%). The age range of patients included in this study was 0 to 19 years (34.9%), 20 to 39 years (31.1%), 40 to 59 years (22.8%), and over 60 years (6.5%). Histologic variants of MC were noted in 46 cases (31 pseudocystic, 8 giant, and 7 pedunculated). An underlying abscess was present in 65 cases. Of the 578 cases, 22 were associated with other lesions (3.8%). There were 9 cases of epidermal cysts, 4 of nevocellular nevi, 3 of metaplastic ossifications, 2 of true epidermal nevi, 2 of sebaceous hyperplasias, 2 of soft fibromas, and 1 of Kaposi sarcoma. Except in immunocompromised patients, such associations are likely to be coincidental. The clinical diagnosis was correct in 42.3% of the cases. Clinical accuracy varied according to the age, localization, and histologic pattern of MC. Pseudocystic MC, giant MC, and MC associated with other lesions were responsible for frequent clinical misdiagnosis.
传染性软疣（MC）很少与其他皮肤病相关，尤其是皮肤肿瘤。这种关联极为罕见，且发生频率未知。本研究的目的是记录一大系列连续MC病例中相关病变的组织学变异和频率。我们回顾了法国斯特拉斯堡大学医院皮肤病理学实验室（1959 - 1999年）的578例MC病例。MC的发病部位如下：头颈部（34.7%）、躯干（27.1%）、下肢（20.7%）、上肢（8.7%）和生殖器（3.8%）。传染性软疣在女性患者中更常见（56.7%）。本研究纳入患者的年龄范围为0至19岁（34.9%）、20至39岁（31.1%）、40至59岁（22.8%）和60岁以上（6.5%）。46例（31例假囊肿型、8例巨大型和7例带蒂型）记录了MC的组织学变异。65例存在潜在脓肿。在578例病例中，22例与其他病变相关（3.8%）。有9例表皮囊肿、4例痣细胞痣、3例化生骨化、2例真性表皮痣、2例皮脂腺增生、2例软纤维瘤和1例卡波西肉瘤。除免疫功能低下患者外，这种关联可能是巧合。42.3%的病例临床诊断正确。临床准确性因MC的年龄、部位和组织学模式而异。假囊肿型MC、巨大型MC以及与其他病变相关的MC常导致临床误诊。
