Yoshizumi M, Tsuchiya K, Tamaki T
Department of Pharmacology, The University of Tokushima School of Medicine, Kuramoto-cho, Tokushima 770-8503, Japan.
J Med Invest. 2001 Feb;48(1-2):11-24.
Reactive oxygen species (ROS), generated by reduction-oxidation (redox) reactions, have been recognized as important chemical mediators that regulate signal transduction. It has been reported that increase in ROS generation may relate to a risk for cardiovascular diseases such as atherosclerosis, angina pectoris, and myocardial infarction. Therefore, understanding the ROS-generating biological processes and ROS-induced intracellular signaling will be informative to gain insights into the pathogenesis of these diseases. In this review, we focus on the sources and reactions of ROS in the cardiovascular system and the role of mitogen-activated protein (MAP) kinase pathway in redox-mediated signal transduction. Clinical implications of ROS and MAP kinase are then described to provide insight into the pathogenesis of various redox-sensitive cardiovascular diseases. The pathways responsible for ROS generation in the cardiovascular system may provide novel therapeutic targets.
由氧化还原反应产生的活性氧（ROS）已被公认为调节信号转导的重要化学介质。据报道，ROS生成增加可能与动脉粥样硬化、心绞痛和心肌梗死等心血管疾病的风险有关。因此，了解产生ROS的生物学过程以及ROS诱导的细胞内信号传导将有助于深入了解这些疾病的发病机制。在本综述中，我们重点关注心血管系统中ROS的来源和反应，以及丝裂原活化蛋白（MAP）激酶途径在氧化还原介导的信号转导中的作用。然后描述了ROS和MAP激酶的临床意义，以深入了解各种氧化还原敏感型心血管疾病的发病机制。心血管系统中负责ROS生成的途径可能提供新的治疗靶点。
