[不明原因复发性自然流产女性外周血中T淋巴细胞及CD4 +辅助性T细胞亚群的变化]
[Changes of T lymphocyte and CD4+ T helper subsets in peripheral blood from women with unexplained recurrent spontaneous abortion].
作者信息
Mao L, Yang P, Yan Y
机构信息
Department of Immunology, Tainjin Medical University, Tianjin 300070, China.
出版信息
Zhonghua Fu Chan Ke Za Zhi. 2000 Dec;35(12):722-3.
OBJECTIVE
To investigate the relationship between occurrence of unexplained recurrent spontaneous abortion(URSA) and immune function of T lymphocytes.
METHODS
T lymphocyte subsets and CD4+ T helper subsets (including T helper 1 and T helper 2 cells) in peripheral blood from 30 cases with URSA and 24 healthy women (controls) were detected by enzyme-linked immunospot assay (ELISPOT).
RESULTS
The percentage of CD4+ positive T lymphocytes in URSA group was higher than that in the controls (60% vs 45%, P < 0.05). Compared with the normal group, the percentage of Th1 cells increased (26% vs 14%, P < 0.01) but the percentage of Th2 cells decreased (7% vs 20%, P < 0.05), the ratio of Th1 to Th2 increased (3.80 vs 0.73, P < 0.01) in the URSA group.
CONCLUSIONS
The occurrence of URSA might be associated with proliferation of the CD4+ positive T cells and enhancement of cellular immune function mediated by Th1 cells.
目的
探讨原因不明复发性自然流产（URSA）的发生与T淋巴细胞免疫功能之间的关系。
方法
采用酶联免疫斑点法（ELISPOT）检测30例URSA患者和24例健康女性（对照组）外周血中的T淋巴细胞亚群及CD4⁺辅助性T细胞亚群（包括辅助性T细胞1和辅助性T细胞2）。
结果
URSA组CD4⁺阳性T淋巴细胞百分比高于对照组（60%对45%，P<0.05）。与正常组相比，URSA组Th1细胞百分比升高（26%对14%，P<0.01），而Th2细胞百分比降低（7%对20%，P<0.05），Th1/Th2比值升高（3.80对0.73，P<0.01）。
结论
URSA的发生可能与CD4⁺阳性T细胞增殖及Th1细胞介导的细胞免疫功能增强有关。
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