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蛔虫胆道移行症的非侵入性管理:对来自厄瓜多尔的69例患者的前瞻性研究

Non-invasive management of Ascaris lumbricoides biliary tact migration: a prospective study in 69 patients from Ecuador.

作者信息

González A H, Regalado V C, Van den Ende J

机构信息

Department of Gastroenterology, Regional Hospital Vincente Corral Moscoso, Public Health Ministry, Cuenca, Ecuador.

出版信息

Trop Med Int Health. 2001 Feb;6(2):146-50. doi: 10.1046/j.1365-3156.2001.00657.x.

Abstract

Ascariasis is one of the most common helminthic diseases. Its most feared complication is migration into the biliary tree. Some authors recommend immediate duodenoscopy in all cases of biliary migration, with sphincterotomy for the extraction of the parasites, and surgical extraction in case of intrahepatic ascariasis. We followed prospectively 69 patients with ultrasonographical evidence of migration. Initial treatment consisted of intravenous analgesics and antispasmodics, and albendazole 800 mg by mouth. Only patients with persisting symptoms or with high amylasaemia underwent duodenoscopy, with extraction in case of a visible worm. Surgery was limited to cases with persistent or progressive complications. In 97% of our cases the worms disappeared with noninvasive therapy alone. A duodenoscopy was done in 30 (42%) cases; in 10 (14%) a worm was found in the ampulla of Vater and extracted without sphincterotomy. In none of the 6 cases with A. lumbricoides in the intrahepatic biliary tree did the parasite persist. Only one patient required surgical intervention. Treatment of A. lumbricoides migration to the biliary tract should be principally medical. Duodenoscopy with extraction of a visible worm should be limited to cases with persisting pain and/or hyperamylasaemia. Invasive methods like sphincterotomy and surgery should be restricted to patients who do not respond to conservative treatment.

摘要

蛔虫病是最常见的蠕虫病之一。其最可怕的并发症是虫体移行至胆道系统。一些作者建议,对于所有胆道移行病例均应立即进行十二指肠镜检查,通过括约肌切开术取出寄生虫;对于肝内蛔虫病,则应进行手术取出。我们前瞻性地随访了69例有超声证据显示存在移行的患者。初始治疗包括静脉注射镇痛药和解痉药,以及口服阿苯达唑800mg。只有症状持续或存在高淀粉酶血症的患者才进行十二指肠镜检查,若发现可见虫体则予以取出。手术仅限于出现持续性或进行性并发症的病例。在我们的病例中,97%的患者仅通过非侵入性治疗虫体就消失了。30例(42%)患者进行了十二指肠镜检查;其中10例(14%)在十二指肠乳头发现虫体,未行括约肌切开术即予以取出。6例肝内胆管有蛔虫的患者中,无一例虫体持续存在。仅1例患者需要手术干预。蛔虫移行至胆道的治疗应以药物治疗为主。对于疼痛持续和/或存在高淀粉酶血症的病例,才应进行十二指肠镜检查并取出可见虫体。像括约肌切开术和手术这样的侵入性方法应仅限于对保守治疗无反应的患者。

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