Hoggard N, Crabtree J, Allstaff S, Abramovich D R, Haggarty P
ACERO, Department of Molecular Physiology, Rowett Research Institute, Aberdeen, Scotland, UK.
Placenta. 2001 Apr;22(4):347-52. doi: 10.1053/plac.2001.0628.
The contribution of placental leptin, if any, to both the fetal and maternal circulation and its role in pregnancy remains to be determined. In an experiment to investigate this, 27 placentae from term pregnancies were perfused ex vivo (gestational age=39.5 s.d. 1.2; range=38-42 weeks: fetal weight=3285 s.d. 482; range=2480-4420; birthweight centile range=4th to the 98th) at both the maternal and fetal interface. Placental leptin was exported into both the maternal and fetal circulations. The log leptin production by the maternal side of the placenta was significantly greater (P=0.001) than that for the fetal side (5.193 s.d.1.049 versus 4.387 s.d. 0.768 ng/placenta/min). There was no significant relationship between maternal and fetal log leptin production and maternal body mass index, birthweight, birthweight centile, ponderal index or gestational age or with cord blood pO(2), pCO(2) and pH. There was however, a significant increase in the maternal log leptin production with increasing fetal to placental weight ratio (P=0.017; r(2)=20.7 per cent) but no corresponding relationship for fetal leptin production. It is proposed that such a mechanism would allow the placenta to modulate fat supply to the fetus in response to the fetal demand relative to placental supply.
胎盘瘦素对胎儿和母体循环的贡献（若有）及其在妊娠中的作用仍有待确定。在一项对此进行研究的实验中，对27个足月妊娠胎盘（胎龄=39.5标准差1.2；范围=38 - 42周：胎儿体重=3285标准差482；范围=2480 - 4420；出生体重百分位数范围=第4至第98百分位）在母体和胎儿界面进行了离体灌注。胎盘瘦素被输出到母体和胎儿循环中。胎盘母体侧的瘦素产生对数显著高于（P = 0.001）胎儿侧（5.193标准差1.049对4.387标准差0.768纳克/胎盘/分钟）。母体和胎儿瘦素产生对数与母体体重指数、出生体重、出生体重百分位数、 ponderal指数或胎龄，或与脐血pO₂、pCO₂和pH之间均无显著关系。然而，随着胎儿与胎盘重量比的增加，母体瘦素产生对数显著增加（P = 0.017；r² = 20.7%），但胎儿瘦素产生无相应关系。有人提出，这样一种机制将使胎盘能够根据相对于胎盘供应的胎儿需求来调节对胎儿的脂肪供应。
