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新型人乳头瘤病毒诊断方法能否改善宫颈癌防控工作?

Will New Human Papillomavirus Diagnostics Improve Cervical Cancer Control Efforts?

作者信息

Kulasingam Shalini L., Koutsky Laura A.

机构信息

University of Washington, HPV Research Group, Suite 300, 1914 N. 34th Street, Seattle, WA 98103, USA.

出版信息

Curr Infect Dis Rep. 2001 Apr;3(2):169-182. doi: 10.1007/s11908-996-0054-0.

DOI:10.1007/s11908-996-0054-0
PMID:11286660
Abstract

With the causal link between specific types of human papillomavirus (HPV) and cervical cancer firmly established, efforts have turned to assessing the relative merits of offering HPV testing in screening, triage, and posttreatment management. Many unanswered questions remain, but a growing body of evidence supports a role for HPV testing in cervical cancer prevention programs. Already, clinical centers that serve thousands of women in Europe and the United States have incorporated HPV DNA tests in triage algorithms.

摘要

随着特定类型的人乳头瘤病毒(HPV)与宫颈癌之间的因果联系被牢固确立,人们的努力已转向评估在筛查、分流和治疗后管理中进行HPV检测的相对优势。许多问题仍未得到解答,但越来越多的证据支持HPV检测在宫颈癌预防项目中发挥作用。在欧洲和美国,已经有服务数千名女性的临床中心将HPV DNA检测纳入了分流算法。

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Comparison of three management strategies for patients with atypical squamous cells of undetermined significance: baseline results from a randomized trial.意义不明确的非典型鳞状细胞患者三种管理策略的比较:一项随机试验的基线结果。
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采用杂交捕获II试验检测人乳头瘤病毒:一种用于筛选宫颈涂片正常但有发生宫颈病变风险女性的可靠检测方法。
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Lancet. 2000 Jun 24;355(9222):2194-8. doi: 10.1016/S0140-6736(00)02402-8.
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Human papillomavirus testing in women with mild cytologic atypia.
Obstet Gynecol. 2000 Jun;95(6 Pt 1):821-7. doi: 10.1016/s0029-7844(00)00795-x.
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Human papillomavirus DNA testing for cervical cancer screening in low-resource settings.在资源匮乏地区进行人乳头瘤病毒DNA检测用于宫颈癌筛查
J Natl Cancer Inst. 2000 May 17;92(10):818-25. doi: 10.1093/jnci/92.10.818.
7
High-risk HPV DNA detection by Hybrid Capture II. An adjunctive test for mildly abnormal cytologic smears in women > or = 50 years of age.采用第二代杂交捕获法检测高危型人乳头瘤病毒DNA。对50岁及以上女性轻度异常细胞学涂片的辅助检测。
J Reprod Med. 2000 Apr;45(4):345-50.
8
Human papillomavirus testing for triage of women with cytologic evidence of low-grade squamous intraepithelial lesions: baseline data from a randomized trial. The Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesions Triage Study (ALTS) Group.人乳头瘤病毒检测用于对有低度鳞状上皮内病变细胞学证据的女性进行分流:一项随机试验的基线数据。意义不明确的非典型鳞状细胞/低度鳞状上皮内病变分流研究(ALTS)组。
J Natl Cancer Inst. 2000 Mar 1;92(5):397-402. doi: 10.1093/jnci/92.5.397.
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Incidence of cervical squamous intraepithelial lesions in HIV-infected women.感染人类免疫缺陷病毒的女性宫颈鳞状上皮内病变的发病率
JAMA. 2000 Feb 23;283(8):1031-7. doi: 10.1001/jama.283.8.1031.
10
Human papillomavirus testing for primary cervical cancer screening.用于原发性宫颈癌筛查的人乳头瘤病毒检测
JAMA. 2000 Jan 5;283(1):108-9. doi: 10.1001/jama.283.1.108.