炎症性肠病中T细胞凋亡的调控：生死抉择，这是黏膜面临的问题。

Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question.

作者信息

Neurath M F, Finotto S, Fuss I, Boirivant M, Galle P R, Strober W

机构信息

Laboratory of Immunology, I. Medical Clinic, University of Mainz, 55131, Mainz, Germany.

出版信息

Trends Immunol. 2001 Jan;22(1):21-6. doi: 10.1016/s1471-4906(00)01798-1.

DOI:10.1016/s1471-4906(00)01798-1

PMID:11286687

Abstract

T-cell resistance against apoptosis contributes to inappropriate T-cell accumulation and the perpetuation of chronic mucosal inflammation in inflammatory bowel diseases (IBDs). Anti-interleukin-12 (IL-12) and anti-IL-6 receptor antibodies suppress colitis activity by the induction of T-cell apoptosis. These findings have important implications for the design of effective treatment regimens in IBD.

摘要

T细胞对细胞凋亡的抗性导致不适当的T细胞积累以及炎症性肠病（IBD）中慢性粘膜炎症的持续存在。抗白细胞介素12（IL-12）和抗IL-6受体抗体通过诱导T细胞凋亡来抑制结肠炎活性。这些发现对IBD有效治疗方案的设计具有重要意义。