细胞凋亡与声带疾病：上皮细胞死亡的临床相关意义
Apoptosis and Vocal Fold Disease: Clinically Relevant Implications of Epithelial Cell Death.
作者信息
Novaleski Carolyn K, Carter Bruce D, Sivasankar M Preeti, Ridner Sheila H, Dietrich Mary S, Rousseau Bernard
机构信息
Department of Hearing and Speech Sciences, School of Medicine, Vanderbilt University, Nashville, TN.
Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN.
出版信息
J Speech Lang Hear Res. 2017 May 24;60(5):1264-1272. doi: 10.1044/2016_JSLHR-S-16-0326.
PURPOSE
Vocal fold diseases affecting the epithelium have a detrimental impact on vocal function. This review article provides an overview of apoptosis, the most commonly studied type of programmed cell death. Because apoptosis can damage epithelial cells, this article examines the implications of apoptosis on diseases affecting the vocal fold cover.
METHOD
A review of the extant literature was performed. We summarized the topics of epithelial tissue properties and apoptotic cell death, described what is currently understood about apoptosis in the vocal fold, and proposed several possible explanations for how the role of abnormal apoptosis during wound healing may be involved in vocal pathology.
RESULTS AND CONCLUSIONS
Apoptosis plays an important role in maintaining normal epithelial tissue function. The biological mechanisms responsible for vocal fold diseases of epithelial origin are only beginning to emerge. This article discusses speculations to explain the potential role of deficient versus excessive rates of apoptosis and how disorganized apoptosis may contribute to the development of common diseases of the vocal folds.
目的
影响上皮的声带疾病会对发声功能产生不利影响。这篇综述文章概述了凋亡，这是最常被研究的程序性细胞死亡类型。由于凋亡会损伤上皮细胞，本文探讨了凋亡对影响声带覆盖层疾病的影响。
方法
对现有文献进行综述。我们总结了上皮组织特性和凋亡性细胞死亡的主题，描述了目前对声带凋亡的理解，并提出了几种可能的解释，说明异常凋亡在伤口愈合过程中的作用如何可能与嗓音病理学相关。
结果与结论
凋亡在维持正常上皮组织功能中起重要作用。上皮源性声带疾病的生物学机制才刚刚开始显现。本文讨论了一些推测，以解释凋亡率不足与过高的潜在作用，以及凋亡紊乱如何可能导致常见声带疾病的发生。
Zotero 插件