自然杀伤细胞受体的趋异进化和趋同进化。

Divergent and convergent evolution of NK-cell receptors.

作者信息

Barten R, Torkar M, Haude A, Trowsdale J, Wilson M J

机构信息

Immunology Division, Dept of Pathology, University of Cambridge, UK.

出版信息

Trends Immunol. 2001 Jan;22(1):52-7. doi: 10.1016/s1471-4906(00)01802-0.

DOI:10.1016/s1471-4906(00)01802-0

PMID:11286693

Abstract

Natural killer (NK)-cell receptors specific for major histocompatibility complex (MHC) class I molecules have been identified in humans and mice. Some of the most important receptors are structurally unrelated in the two species: the murine Ly-49 receptors are C-type lectins, while human killer-cell inhibitory receptors (KIRs) belong to the immunoglobulin superfamily. Here, Roland Barten and colleagues describe the divergent and convergent evolution of NK-cell receptors.

摘要

在人类和小鼠中已鉴定出对主要组织相容性复合体（MHC）I类分子具有特异性的自然杀伤（NK）细胞受体。其中一些最重要的受体在这两个物种中的结构不相关：小鼠的Ly-49受体是C型凝集素，而人类杀伤细胞抑制受体（KIR）属于免疫球蛋白超家族。在此，罗兰·巴滕及其同事描述了NK细胞受体的趋异进化和趋同进化。