Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Stagno d'Alcontres, 31, 98166 Messina, Italy.
Department of Clinical and Experimental Medicine, University of Messina, Viale Gazzi, 98147 Messina, Italy.
Molecules. 2022 Mar 17;27(6):1953. doi: 10.3390/molecules27061953.
Psoriasis is one of the most widespread chronic inflammatory skin diseases, affecting about 2%-3% of the worldwide adult population. The pathogenesis of this disease is quite complex, but an interaction between genetic and environmental factors has been recognized with an essential modulation of inflammatory and immune responses in affected patients. Psoriatic plaques generally represent the clinical psoriatic feature resulting from an abnormal proliferation and differentiation of keratinocytes, which cause dermal hyperplasia, skin infiltration of immune cells, and increased capillarity. Some scientific pieces of evidence have reported that psychological stress may play a key role in psoriasis, and the disease itself may cause stress conditions in patients, thus reproducing a vicious cycle. The present review aims at examining immune cell involvement in psoriasis and the relationship of depression and stress in its pathogenesis and development. In addition, this review contains a focus on the possible use of natural products, thus pointing out their mechanism of action in order to counteract clinical and psychological symptoms.
银屑病是最广泛的慢性炎症性皮肤病之一，影响全球约 2%-3%的成年人口。这种疾病的发病机制相当复杂，但已认识到遗传和环境因素之间的相互作用，受影响患者的炎症和免疫反应受到重要调节。银屑病斑块通常代表由角质形成细胞异常增殖和分化引起的临床银屑病特征，导致真皮增生、免疫细胞浸润和毛细血管增加。一些科学证据表明，心理压力可能在银屑病中起关键作用，而且疾病本身可能会导致患者出现应激状态，从而形成恶性循环。本综述旨在研究免疫细胞在银屑病中的作用以及抑郁和压力在其发病机制和发展中的关系。此外，本综述还重点介绍了天然产物的可能用途，从而指出其作用机制，以对抗临床和心理症状。
