Gerli R, Lunardi C, Vinante F, Bistoni O, Pizzolo G, Pitzalis C
Section of Internal Medicine and Oncological Sciences, Department of Clinical and Experimental Medicine, Center for the Study of Rheumatic Diseases, University of Perugia, I-06122, Perugia, Italy.
Trends Immunol. 2001 Feb;22(2):72-7. doi: 10.1016/s1471-4906(00)01829-9.
CD30 has been proposed to identify Th0/2-type clones. However, the in vivo relevance of this finding is still a matter of debate, as high serum levels of soluble CD30 have been found in both Th1- and Th2- dominated disorders. Among these, rheumatoid arthritis represents a condition where the Th1 predominance is combined with the presence of CD30(+) T-cell activity, particularly in specific stages of the disease. This article discusses the hypothesis that CD30(+) T cells might play a counter-regulatory role at sites of inflammation in Th1-mediated conditions, such as rheumatoid arthritis.
CD30已被提出用于识别Th0/2型克隆。然而，这一发现的体内相关性仍存在争议，因为在以Th1和Th2为主导的疾病中均发现血清可溶性CD30水平升高。其中，类风湿性关节炎是一种Th1优势与CD30(+) T细胞活性并存的疾病，尤其是在疾病的特定阶段。本文讨论了一个假说，即CD30(+) T细胞可能在Th1介导的疾病（如类风湿性关节炎）的炎症部位发挥反调节作用。
