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动态弧形放射外科治疗的射野塑形:与静态射野适形和非共面圆弧的比较

Dynamic arc radiosurgery field shaping: a comparison with static field conformal and noncoplanar circular arcs.

作者信息

Solberg T D, Boedeker K L, Fogg R, Selch M T, DeSalles A A

机构信息

Department of Radiation Oncology, UCLA School of Medicine, Los Angeles, CA, USA.

出版信息

Int J Radiat Oncol Biol Phys. 2001 Apr 1;49(5):1481-91. doi: 10.1016/s0360-3016(00)01537-6.

Abstract

PURPOSE

Recent advances in field-shaping technology and linac multileaf collimator (MLC) integration have resulted in new approaches to performing stereotactic radiosurgery. We present a modeling study comparing the absolute dose distributions from three radiosurgery delivery techniques: a conventional approach utilizing noncoplanar circular arcs, a static field conformal approach, and a dynamic arc field-shaping approach. In the latter, the MLC leaves more in a continuous fashion, conforming to the beam's-eye-view projection of the target at every increment along the path of an arc.

METHODS AND MATERIALS

For the analysis, we devised a simulated target consisting of three overlapping spheres. This was chosen because it offered a straightforward planning approach for all three techniques, primarily the multiple isocenter approach. In addition, three representative cases were selected from the prior radiosurgery experience. These range in increasing size, from 0.50 to 9.79 cm(3), and in complexity, requiring from 3 isocenters to 16 in the case of circular arcs. In each situation, the goals were twofold: (1) to cover the entire volume with as high an appropriate isodose level (90% in the case of the conformal and dynamic arc techniques, 50% in the case of circular collimators) while (2) minimizing the dose to normal brain and where applicable, any adjacent radiation-sensitive structures. Because of the latter requirement, a single isocenter circular arc approach was ruled out for the analysis.

RESULTS

In the case of large or irregularly shaped lesions, the circular arc technique requires multiple isocenters, producing a high level of dose heterogeneity within the target volume. Both the static field and dynamic arc conformal techniques, as with all single isocenter approaches, produce a highly homogeneous dose throughout the target region. For a given large dose, peripheral dose is decreased as additional beams or arc degrees are added with either of the conformal approaches. Dose--volume histogram analysis evaluating the peripheral dose shows that, in many cases, dose to surrounding structures can be reduced through the use of a conformal static or dynamic arc approach over the conventional multiple isocenter, circular arc techniques.

CONCLUSIONS

Dynamic arc shaping is an efficient and effective method for accurately delivering a homogeneous target dose while simultaneously minimizing peripheral dose in radiosurgery applications.

摘要

目的

射野塑形技术和直线加速器多叶准直器(MLC)集成方面的最新进展带来了立体定向放射外科的新方法。我们进行了一项建模研究,比较三种放射外科治疗技术的绝对剂量分布:一种采用非共面圆弧的传统方法、一种静态野适形方法和一种动态弧形野塑形方法。在动态弧形野塑形方法中,MLC叶片以连续方式运动,在沿弧形路径的每个增量处都与靶区的射束视场投影相匹配。

方法和材料

为进行分析,我们设计了一个由三个重叠球体组成的模拟靶区。选择这种靶区是因为它为所有三种技术,主要是多等中心方法,提供了一种直接的计划制定方法。此外,从先前的放射外科治疗经验中选取了三个具有代表性的病例。这些病例的大小逐渐增大,从0.50立方厘米到9.79立方厘米,复杂性也不断增加,在采用圆弧技术的情况下,等中心数量从3个到16个不等。在每种情况下,目标有两个:(1)用尽可能高的合适等剂量水平覆盖整个体积(适形和动态弧形技术为90%,圆形准直器为50%),同时(2)将对正常脑组织以及适用时对任何相邻放射敏感结构的剂量降至最低。由于后一项要求,分析中排除了单等中心圆弧方法。

结果

对于大的或形状不规则的病变,圆弧技术需要多个等中心,导致靶区内剂量不均匀性较高。静态野和动态弧形适形技术,与所有单等中心方法一样,在整个靶区内产生高度均匀的剂量。对于给定的大剂量,采用任何一种适形方法增加额外的射束或弧度数时,周边剂量会降低。评估周边剂量的剂量体积直方图分析表明,在许多情况下,与传统的多等中心圆弧技术相比,采用适形静态或动态弧形方法可降低对周围结构的剂量。

结论

在放射外科应用中,动态弧形塑形是一种准确输送均匀靶区剂量同时将周边剂量降至最低的高效方法。

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