Unfried G, Tempfer C, Schneeberger C, Widmar B, Nagele F, Huber J C
Department of Gynecologic Endocrinology and Reproductive Medicine, University Hospital of Vienna, Vienna, Austria.
Fertil Steril. 2001 Apr;75(4):683-7. doi: 10.1016/s0015-0282(01)01675-2.
Proinflammatory cytokines have been described as etiologic factors in idiopathic recurrent miscarriage. We investigated the relation between idiopathic recurrent miscarriage and polymorphisms in the gene encoding for the interleukin 1 receptor antagonist, an indigenous modulator of proinflammatory immune response.
Prospective case control study.
Academic research institution.
PATIENT(S): One hundred five women with a history of three or more consecutive pregnancy losses before 20 weeks of gestation and 91 healthy, postmenopausal controls with at least two live births and no history of pregnancy loss.
INTERVENTION(S): Peripheral venous puncture.
MAIN OUTCOME MEASURE(S): Polymerase chain reaction was performed to identify the different alleles of the gene encoding for interleukin 1 receptor antagonist.
RESULT(S): Allele frequencies among women with idiopathic recurrent miscarriage and controls were 0.34 and 0.11, respectively, for the polymorphic allele 2 (P=.002; odds ratio: 7.4, confidence interval: 2.9--10.8) and.05 and.05, respectively, for the polymorphic allele 3 (P=.6; odds ratio: 1.3, confidence interval: 0.8--2.3). Allele 2 was present in homozygous form in 9% of women with idiopathic recurrent miscarriage. In contrast, 1% of the control women were homozygous for this allele (P<.001; odds ratio: 13.5, confidence interval: 7.5--21.8).
CONCLUSION(S): These data support a role for allele 2 of the gene encoding for interleukin 1 receptor antagonist as genetic determinant of idiopathic recurrent miscarriage.
促炎细胞因子已被描述为特发性复发性流产的病因。我们研究了特发性复发性流产与白细胞介素1受体拮抗剂（促炎免疫反应的一种内源性调节剂）编码基因多态性之间的关系。
前瞻性病例对照研究。
学术研究机构。
105名有妊娠20周前连续三次或更多次流产史的女性，以及91名健康的绝经后对照者，她们至少有两次活产且无流产史。
外周静脉穿刺。
采用聚合酶链反应来鉴定白细胞介素1受体拮抗剂编码基因的不同等位基因。
特发性复发性流产女性和对照者中，多态性等位基因2的等位基因频率分别为0.34和0.11（P = 0.002；比值比：7.4，置信区间：2.9 - 10.8），多态性等位基因3的等位基因频率分别为0.05和0.05（P = 0.6；比值比：1.3，置信区间：0.8 - 2.3）。等位基因2以纯合形式存在于9%的特发性复发性流产女性中。相比之下，1%的对照女性为该等位基因的纯合子（P < 0.001；比值比：13.5，置信区间：7.5 - 21.8）。
这些数据支持白细胞介素1受体拮抗剂编码基因的等位基因2作为特发性复发性流产的遗传决定因素发挥作用。
