Silva C L, Bonato V L, Lima K M, Coelho-Castelo A A, Faccioli L H, Sartori A, De Souza A O, Leão S C
Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
FEMS Microbiol Lett. 2001 Apr 1;197(1):11-8. doi: 10.1111/j.1574-6968.2001.tb10575.x.
How the immune system kills Mycobacterium tuberculosis is still a puzzle. The classical picture of killing due to phagocytosis by activated macrophages may be only partly correct. Based on recent evidence, we express here the view that cytotoxic T lymphocytes also make an important contribution and suggest that DNA vaccines might be a good way to enhance this.
免疫系统如何杀死结核分枝杆菌仍是一个谜。传统观点认为，激活的巨噬细胞通过吞噬作用来杀死细菌，这可能只部分正确。基于最近的证据，我们在此表达这样一种观点：细胞毒性T淋巴细胞也发挥了重要作用，并认为DNA疫苗可能是增强这一作用的好方法。
