Kerdpon D, Sriplung H
Stomatology Department, Faculty of Dentistry, Prince of Songkla University, Haad Yai, 90112, Songkhla, Thailand.
Oral Oncol. 2001 Apr;37(3):216-21. doi: 10.1016/s1368-8375(00)00067-1.
A critical factor that indicates a poor prognosis of oral squamous cell carcinoma (OSCC) is advanced stage disease. This study, therefore, aimed to identify the factors related to advanced stage (TNM staging III, IV) OSCC in Thailand. There were 161 patients with squamous cell carcinoma of the oral cavity and lip (ICD-9 140, 141, 143-5), included in the study. Sixty-two per cent of the patients presented with advanced stage disease. Information on demographic characteristics, risk habits, health-seeking behaviour prior to health care professional (HCP) consultation, tumour characteristics and patient and professional delay was obtained by questionnaire-based interview of the patients. These variables were included as initial variables in a logistic regression to calculate the odds ratio (OR) of advanced versus early stage OSCC. Having traditional herbal medication before HCP consultation significantly increased the risk of advanced stage OSCC (OR 5.77; 95% C.I. 1.25-26.62). Floor of mouth location of tumour was associated with a lower risk of advanced stage disease (OR 0.27; 95% C.I. 0.09-0.82) as was having an ulcer (OR 0.43, 95% C.I. 0.02-0.89). The findings indicate that having traditional herbal medication before HCP consultation increased the risk of advanced stage disease. The lower risk of advanced stage OSCC associated with ulcerative tumours and those on the floor of the mouth may be due to their being more readily detected by the patients.
口腔鳞状细胞癌（OSCC）预后不良的一个关键因素是疾病处于晚期。因此，本研究旨在确定泰国晚期（TNM分期III、IV期）OSCC的相关因素。本研究纳入了161例口腔和唇部鳞状细胞癌患者（国际疾病分类第九版编码140、141、143 - 145）。62%的患者表现为晚期疾病。通过对患者进行基于问卷的访谈，获取了人口统计学特征、风险习惯、在咨询医疗保健专业人员（HCP）之前的就医行为、肿瘤特征以及患者和专业人员延误等信息。这些变量作为初始变量纳入逻辑回归分析，以计算晚期与早期OSCC的比值比（OR）。在咨询HCP之前使用传统草药显著增加了晚期OSCC的风险（OR 5.77；95%置信区间1.25 - 26.62）。肿瘤位于口底与晚期疾病风险较低相关（OR 0.27；95%置信区间0.09 - 0.82），溃疡也是如此（OR 0.43，95%置信区间0.02 - 0.89）。研究结果表明在咨询HCP之前使用传统草药会增加晚期疾病的风险。与溃疡性肿瘤和口底肿瘤相关的晚期OSCC风险较低可能是因为患者更容易发现这些肿瘤。
