Tangthongkum Manupol, Tiyanuchit Sireethorn, Kirtsreesakul Virat, Supanimitjaroenporn Pasawat, Sinkitjaroenchai Wattana
Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
Eur Arch Otorhinolaryngol. 2017 Nov;274(11):3985-3992. doi: 10.1007/s00405-017-4734-1. Epub 2017 Sep 2.
Although platelet to lymphocyte ratio (PLR) and red cell distribution width (RDW) have been reported as good predictors for survival outcomes in various cancers, there is limited data supporting these as reliable predictors in oral cancer. This study thus aimed to assess the prognostic value of PLR and RDW markers in predicting survival and recurrence rates in patients with oral cancer. The records of 374 oral cancer patients treated with curative intent over a 7-year period (2009-2015) were reviewed. Survival and recurrence outcomes were compared between those with low and high PLR (≤135 vs. >135) and those with low and high RDW (≤14.05 vs. >14.05) using hazard ratios (HR). The 5-year disease-specific survival was significantly higher and recurrence rate significantly lower among the low PLR group compared to the high PLR group (65.7 vs. 37.6%; p < 0.001 and 34.4 and 57.5%; p < 0.001), respectively. There were no significant differences between the low and high RDW groups for disease-specific survival (53.6 vs. 54.7%, p = 0.408) and recurrence (40.0% vs. 53.8%, p = 0.079). Multivariate analysis showed that PLR was associated with disease-specific survival (HR = 2.05, p < 0.001) and recurrence (HR = 1.69, p < 0.005) after adjusting for other factors, but not RDW. High PLR shows promise as a prognostic predictor for poor survival and recurrence in patients with oral cancer, but further studies are required. RDW has no prognostic value on any outcome.
尽管血小板与淋巴细胞比值（PLR）和红细胞分布宽度（RDW）已被报道为多种癌症生存结果的良好预测指标，但在口腔癌中，支持它们作为可靠预测指标的数据有限。因此，本研究旨在评估PLR和RDW标志物在预测口腔癌患者生存和复发率方面的预后价值。回顾了2009年至2015年期间接受根治性治疗的374例口腔癌患者的记录。使用风险比（HR）比较了低PLR（≤135 vs. >135）和高PLR以及低RDW（≤14.05 vs. >14.05）和高RDW患者的生存和复发结果。与高PLR组相比，低PLR组的5年疾病特异性生存率显著更高，复发率显著更低（分别为65.7% vs. 37.6%；p < 0.001和34.4%和57.5%；p < 0.001）。低RDW组和高RDW组在疾病特异性生存（53.6% vs. 54.7%，p = 0.408）和复发（40.0% vs. 53.8%，p = 0.079）方面没有显著差异。多因素分析表明，在调整其他因素后，PLR与疾病特异性生存（HR = 2.05，p < 0.001）和复发（HR = 1.69，p < 0.005）相关，但与RDW无关。高PLR有望作为口腔癌患者生存不良和复发的预后预测指标，但需要进一步研究。RDW对任何结果均无预后价值。
