Ouchi Y, Kanno T, Okada H, Yoshikawa E, Futatsubashi M, Nobezawa S, Torizuka T, Tanaka K
Positron Medical Center, Hamakita Japan.
Brain. 2001 Apr;124(Pt 4):784-92. doi: 10.1093/brain/124.4.784.
The basal ganglia play a role in controlling movement during gait. The aim of the present study was to investigate changes in dopamine transporter (DAT) availability in the striatum and extrastriatal region in association with walking exercise in six normal subjects and seven age-matched unmedicated patients with Parkinson's disease. This was done by comparing DAT radioligand uptake in the dopaminergic projection areas after gait with that under the resting condition using a DAT probe, 11C-labelled 2-beta-carbomethoxy-3beta-(4-fluorophenyl) tropane ([11C]CFT) and PET. Physiological parameters were stable during and after gait in both groups. The regions of interest method for measuring differences in [11C]CFT uptake level and voxel-based statistical parametric mapping (SPM96) showed that [11C]CFT uptake in the striatum (specifically the putamen) was decreased by gait to a greater extent in normal subjects, whereas a significant reduction in [11C]CFT uptake was not found in the putamen but in the caudate and orbitofrontal cortex in Parkinson's disease patients. These results are the first in vivo evidence that DAT availability is reduced in the nigrostriatal projection area by basic human behaviour, i.e. gait. Alterations in this availability in Parkinson's disease suggested that shifted activation in the medial striatum and the mesocortical dopaminergic system might reflect the pathophysiology of parkinsonian gait.
基底神经节在步态运动控制中发挥作用。本研究的目的是调查6名正常受试者和7名年龄匹配的未经药物治疗的帕金森病患者纹状体和纹状体以外区域多巴胺转运体（DAT）可用性与步行运动相关的变化。通过使用DAT探针11C标记的2-β-甲氧基-3β-（4-氟苯基）托烷（[11C]CFT）和正电子发射断层扫描（PET），比较步态后与静息状态下多巴胺能投射区域中DAT放射性配体摄取情况来实现这一目的。两组在步态期间和之后生理参数均稳定。用于测量[11C]CFT摄取水平差异的感兴趣区域方法和基于体素的统计参数映射（SPM96）显示，正常受试者中，步态使纹状体（特别是壳核）中的[11C]CFT摄取减少的程度更大，而帕金森病患者的壳核中未发现[11C]CFT摄取有显著减少，而是在尾状核和眶额皮质中出现了显著减少。这些结果是首次在体内证明基本人类行为即步态会使黑质纹状体投射区域的DAT可用性降低。帕金森病中这种可用性的改变表明，内侧纹状体和中皮质多巴胺能系统激活的改变可能反映了帕金森步态的病理生理学。
