Barber S, Appleton D R, Kerr D N
Nephron. 1975;14(2):209-27. doi: 10.1159/000180449.
Regular haemodialysis with the Kiil dialyser for 8-10 h three times a week is the present standard of adequate dialysis. In 100 patients treated by this regime there was no positive correlation between plasma urea and creatinine before or after dialysis and any of the symptoms of which these patients still complained. There are no grounds for believing that a further increase in dialysis would relieve residual symptoms. However, any reduction in current standards of dialysis should be justified by prolonged clinical trial of large groups of patients before they are accepted as equivalent in view of the infrequency of some uraemic manifestations such as pericarditis. The implications of the middle molecular hypothesis are discussed.
目前充分透析的标准是使用基尔透析器每周进行3次、每次8至10小时的常规血液透析。采用这种治疗方案治疗的100例患者中，透析前后血浆尿素和肌酐水平与这些患者仍诉说的任何症状之间均无正相关关系。没有理由认为进一步增加透析会缓解残留症状。然而，鉴于某些尿毒症表现（如心包炎）并不常见，在将当前透析标准的任何降低视为等效标准之前，应通过对大量患者进行长期临床试验来证明其合理性。文中还讨论了中分子假说的意义。
