沙眼衣原体抗体与宫颈肿瘤严重程度之间无关联。
No association of anti-Chlamydia trachomatis antibodies and severity of cervical neoplasia.
作者信息
Reesink-Peters N, Ossewaarde J M, Van Der Zee A G, Quint W G, Burger M P, Adriaanse A H
机构信息
Department of Obstetrics and Gynaecology, Academic Medical Centre, University of Amsterdam, The Netherlands.
出版信息
Sex Transm Infect. 2001 Apr;77(2):101-2. doi: 10.1136/sti.77.2.101.
OBJECTIVE
To explore whether the presence of Chlamydia trachomatis antibodies is associated with the severity of neoplastic lesions in women with cervical dyskaryosis.
METHODS
In a cross sectional study in two groups of women referred for an abnormal Papanicolaou smear (group A: 296, group B: 331 women) blood samples were analysed for antichlamydial antibodies by enzyme immunoassay. Cervical neoplasia was graded histologically.
RESULTS
In group A no association was found between increasing grade of CIN and the presence of antichlamydial antibodies. The proportion (93%) of women with antichlamydial antibodies was higher in 14 women with (micro)invasive carcinoma than in women with CIN (35%). As the high prevalence of antichlamydial antibodies in women with cervical carcinoma is not consistent with prevalences reported in recent literature, we analysed a second group of women in which indeed the high prevalence was not confirmed
CONCLUSION
Our results suggest that the presence of circulating antichlamydial antibodies is not associated with the severity of neoplastic lesions and it seems unlikely that C trachomatis has a role in the progression of cervical neoplasia.
目的
探讨沙眼衣原体抗体的存在是否与宫颈发育异常女性肿瘤性病变的严重程度相关。
方法
在一项横断面研究中，对两组因巴氏涂片异常转诊的女性（A组：296名女性，B组：331名女性）的血液样本进行酶免疫分析，检测抗衣原体抗体。对宫颈肿瘤进行组织学分级。
结果
在A组中，未发现CIN分级增加与抗衣原体抗体的存在之间存在关联。14名患有（微）浸润癌的女性中抗衣原体抗体阳性的比例（93%）高于患有CIN的女性（35%）。由于宫颈癌女性中抗衣原体抗体的高患病率与近期文献报道的患病率不一致，我们分析了另一组女性，其中确实未证实高患病率。
结论
我们的结果表明，循环抗衣原体抗体的存在与肿瘤性病变的严重程度无关，沙眼衣原体似乎不太可能在宫颈肿瘤的进展中起作用。
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