Spencer K, Liao A W, Skentou H, Ong C Y, Nicolaides K H
Endocrine Unit, Clinical Biochemistry Department, Harold Wood Hospital, Gubbins Lane, Romford, Essex RM3 0BE, UK.
Prenat Diagn. 2001 Apr;21(4):270-3. doi: 10.1002/pd.53.
Maternal serum total activin-A concentration was measured in 45 pregnancies affected by trisomy 21 and 493 control unaffected pregnancies at 10-14 weeks of gestation. In the trisomy 21 pregnancies total activin-A concentration was significantly higher (1.36 MoM of the unaffected pregnancies) and in 16% of cases the level was above the 95th centile of normal. The log10 SD for the control group and the trisomy 21 group were 0.17 and 0.22, respectively. The median pregnancy associated plasma protein-A (PAPP-A) in this trisomy 21 series was 0.49 and for free beta-hCG was 2.05. In the trisomy group there were significant positive associations between total activin-A and PAPP-A (0.6071) and free beta-hCG (0.4255). The low median difference and the high overlap in values between trisomic and unaffected pregnancies make total activin-A of little practical use in first-trimester screening for trisomy 21.
在妊娠10 - 14周时，对45例21三体妊娠和493例未受影响的对照妊娠测量了母体血清总激活素-A浓度。在21三体妊娠中，总激活素-A浓度显著更高（是未受影响妊娠的1.36倍中位数倍数），并且在16%的病例中该水平高于正常的第95百分位数。对照组和21三体组的log10标准差分别为0.17和0.22。在这个21三体系列中，妊娠相关血浆蛋白-A（PAPP-A）的中位数为0.49，游离β - hCG的中位数为2.05。在三体组中，总激活素-A与PAPP-A（0.6071）和游离β - hCG（0.4255）之间存在显著正相关。三体妊娠和未受影响妊娠之间的低中位数差异和高值重叠使得总激活素-A在孕早期21三体筛查中几乎没有实际用途。
