Prowans P, el Fray M, Jursa J, Walaszek I
Klinika Chirurgii Ogólnej i Chirurgii Reki Pomorskiej Akademii Medycznej w Szczecinie.
Polim Med. 2000;30(3-4):83-7.
In the Technical University of Szczecin, Department of Chemical Fibres and Physical Chemistry of Polymer there has been synthesised a new polymer based on butylene terephthalate--PBT and dimerized fatty acid--DFA. Five different polymers varying in mechanical properties depending on hard segments--PBT and soft segments--DFA composition were obtained. Assessment of biocompatibility of the new materials was conducted according to FDP. Prepared water extracts from polymers were applicated intravenously to mouse and intra-abdominaly to mice and guinea pigs. All animals survived spell of the experiment and no signs of physical degradation were noticed. Kidney, liver, spleen, heart and peritoneum specimens was taken and evaluated microscopically. There was no signs of toxic action of the extracts. Based on principles in FDP and the data from animal studies it is applicable that evaluated materials have no increased toxicity.
在什切青工业大学，化学纤维与聚合物物理化学系合成了一种基于聚对苯二甲酸丁二醇酯（PBT）和二聚脂肪酸（DFA）的新型聚合物。根据硬段（PBT）和软段（DFA）的组成，获得了五种机械性能不同的聚合物。根据FDP对新材料的生物相容性进行了评估。将从聚合物制备的水提取物静脉注射给小鼠，并腹腔注射给小鼠和豚鼠。所有动物在实验期间存活，未观察到身体降解的迹象。采集肾脏、肝脏、脾脏、心脏和腹膜标本并进行显微镜评估。提取物没有毒性作用的迹象。根据FDP的原则和动物研究数据，评估的材料没有增加的毒性是适用的。
