Ruibal A, Arias J I, Del Río M C, Lapeña G, Schneider J, Tejerina A
Nuclear Medicine Service, Jiménez Díaz Foundation, Madrid, Spain.
Int J Biol Markers. 2001 Jan-Mar;16(1):56-61. doi: 10.1177/172460080101600108.
In order to study the association of histological grade (HG) with specific clinical and biological parameters which may influence the clinical behavior of infiltrating ductal carcinomas of the breast (IDC), we analyzed in 229 tissue samples the cytosolic concentrations of estrogen receptor (ER), progesterone receptor (PR), pS2, cathepsin D, hyaluronic acid (HA) and tissue-type plasminogen activator (t-PA), as well as those of the erbB2 oncoprotein, epidermal growth factor receptor (EGFR), HA, CD44v5 and CD44v6 in the cell membrane fraction. Likewise, we considered size, ploidy, S-phase fraction and axillary node involvement as variables of the study. The transition from HG1 to HG2 and from HG2 to HG3 was accompanied by a number of common features: global increase in size, greater number of tumors >2.0 cm, decrease in membrane hyaluronic acid concentrations, increased cell proliferation (S-phase >7%) and greater aneuploidy. Other events observed during the transition from HG2 to HG3 were a decrease in ER, PR, t-PA and cytosolic hyaluronic acid. These results led us to consider that HG is associated with certain clinical-biological changes that may help explain its value as a prognostic factor in breast carcinomas.
为了研究组织学分级（HG）与可能影响乳腺浸润性导管癌（IDC）临床行为的特定临床和生物学参数之间的关联，我们分析了229份组织样本中雌激素受体（ER）、孕激素受体（PR）、pS2、组织蛋白酶D、透明质酸（HA）和组织型纤溶酶原激活剂（t-PA）的胞质浓度，以及细胞膜部分中erbB2癌蛋白、表皮生长因子受体（EGFR）、HA、CD44v5和CD44v6的浓度。同样，我们将肿瘤大小、倍体、S期分数和腋窝淋巴结受累情况作为研究变量。从HG1到HG2以及从HG2到HG3的转变伴随着一些共同特征：肿瘤大小总体增加，直径>2.0 cm的肿瘤数量增多，膜透明质酸浓度降低，细胞增殖增加（S期>7%）以及非整倍体增多。在从HG2到HG3的转变过程中观察到的其他变化包括ER、PR、t-PA和胞质透明质酸减少。这些结果使我们认为，HG与某些临床生物学变化相关，这可能有助于解释其作为乳腺癌预后因素的价值。
