Ruibal A, Sánchez Salmón A
Department of Nuclear Medicine, University Hospital, Faculty of Medicine, Santiago de Compostela - Spain.
Int J Biol Markers. 2008 Jan-Mar;23(1):58-62.
In order to evaluate the influence of hormone dependence on the features of infiltrating ductal carcinoma of the breast we have assayed the cytosolic levels of estrogen receptor (ER), progesterone receptor (PR), pS2 and cathepsin D in 53 women aged over 70 years and in 95 women aged between 55 and 70 years. Tumor size, axillary involvement, distant metastasis, histological grade, ploidy and S-phase were taken into account. Carcinomas of women aged over 70 did not show higher concentrations or higher positive results for ER and PR than those of women in the 55-70-year age group. In older patients, negativity for ER was associated only with higher S-phase fraction, while negativity for PR was not associated with any of the parameters analyzed. In the younger subgroup, negativity for ER was associated with larger tumor size, higher S-phase fraction, lymph node involvement, histological grade 3 and lower pS2 values. Negativity for PR was associated with the same parameters, as well as with a higher frequency of recurrence. Our results suggest a reduced influence of hormone dependence on the clinicopathological features of breast carcinomas in patients older than 70 years compared with women aged between 55 and 70 years.
为了评估激素依赖性对乳腺浸润性导管癌特征的影响，我们检测了53名70岁以上女性和95名55至70岁女性的雌激素受体（ER）、孕激素受体（PR）、pS2和组织蛋白酶D的胞浆水平。同时考虑了肿瘤大小、腋窝受累情况、远处转移、组织学分级、倍体和S期。70岁以上女性的癌组织中，ER和PR的浓度及阳性结果并不高于55至70岁年龄组的女性。在老年患者中，ER阴性仅与较高的S期分数相关，而PR阴性与所分析的任何参数均无关联。在较年轻的亚组中，ER阴性与肿瘤体积较大、S期分数较高、淋巴结受累、组织学3级及较低的pS2值相关。PR阴性与相同参数相关，且复发频率较高。我们的结果表明，与55至70岁的女性相比，激素依赖性对70岁以上乳腺癌患者临床病理特征的影响较小。
